Unfortunately, the specific isoforms that this antibody reacts to have not been investigated. The immunogen is from the C-terminus. Please see the links below to review additional information that may be helpful:
NP_851996
https://www.ncbi.nlm.nih.gov/protein/NP_851996
Entrez Gene 4684 Human
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=4684
156R-9
CD56 (MRQ-42) Rabbit Monoclonal Antibody
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
100
500
conjugado
unconjugated
forma do anticorpo
culture supernatant
tipo de produto de anticorpo
primary antibodies
clone
MRQ-42, monoclonal
descrição
For In Vitro Diagnostic Use in Select Regions (See Chart)
Formulário
buffered aqueous solution
reatividade de espécies
human
embalagem
vial of 0.1 mL concentrate (156R-94)
vial of 0.5 mL concentrate (156R-95)
bottle of 1.0 mL predilute (156R-97)
vial of 1.0 mL concentrate (156R-96)
bottle of 7.0 mL predilute (156R-98)
fabricante/nome comercial
Cell Marque®
técnica(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
Isotipo
IgG1
controle
neuroblastoma
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
visualização
membranous
Informações sobre genes
human ... NCAM1(4684)
Descrição geral
CD56, also known as a neural cell adhesion molecule (NCAM), is a calcium-independenthomophilic binding protein that belongs to a group of cell adhesion molecules includingcadherins, selectins, and integrins. CD56 is involved in cell-cell adhesion of neural cellsduring embryogenesis and is expressed in most neuroectodermally derived tissues. Innormal tissue, anti-CD56 labels neurons, glia, Schwann cells, NK (natural killer) cells, and asubset of T-cells. CD56 expression can be seen in most NK cell neoplasms,4 and is frequentlyused to identify neoplasms with neuroendocrine differentiation.
Qualidade
 IVD |  IVD |  IVD |  RUO |
Ligação
CD56 Positive Control Slides, Product No. 156S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
forma física
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Nota de preparo
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Outras notas
For Technical Service please contact: 800-665-7284 or email: [email protected]
Informações legais
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Jianguo Tao et al.
The American journal of surgical pathology, 26(1), 111-118 (2002-01-05)
We report an unusual case of aggressive natural killer (NK)-like cytotoxic T-cell lymphoma in a previously healthy immunocompetent West African male. He presented with a fever of unknown origin, subsequently developed erythematous skin nodules, generalized lymphadenopathy, and hepatosplenomegaly, and then
R Michalides et al.
International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 34-37 (1994-01-01)
The presence of the neural cell adhesion molecule, NCAM, is indicative for a poor prognosis in lung-cancer patients. Using MAb 735, we have investigated the expression of polysialic acid, PSA, on NCAM in a spectrum of neuro-endocrine lung tumors, ranging
O Kaufmann et al.
Human pathology, 28(12), 1373-1378 (1998-01-07)
CD56 is immunohistochemically detectable in virtually all small cell carcinomas on frozen sections. The authors retrospectively tested the usefulness of the monoclonal antibody 123C3 against CD56 to differentiate pulmonary and extrapulmonary small cell carcinomas from nonneuroendocrine non-small cell carcinomas by
Scott A Ely et al.
The American journal of pathology, 160(4), 1293-1299 (2002-04-12)
Unlike monoclonal gammopathy of undetermined significance (MGUS) or non-Hodgkin's lymphomas (NHLs) with plasmacytoid differentiation, multiple myeloma (MM) is commonly associated with lytic bone lesions. Although the mechanisms of increased osteoclast activity are partially understood, comparatively little is known about the
R Gerardy-Schahn et al.
International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 38-42 (1994-01-01)
Monoclonal antibodies (MAbs) ranked together as small-cell-lung-cancer (SCLC) Cluster I MAbs are directed against the neural cell adhesion molecule NCAM (CD 56) and have been shown to be useful reagents in SCLC diagnosis and therapy. We analyzed the epitopes recognized
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Which isoforms of the CD56 antigen does the CD56 MRQ-42 clone recognize? I am curious about the 120kD, 140kD, and 180 kD isoforms, in particular.
1 answer-
Helpful?
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What is the stability of cut slides for staining with the CD56 MRQ-42 clone, particularly for slides that have been sectioned 6 months to 1 year ago and stored at -20°C with desiccant?
1 answer-
It is generally recommended to begin with fresh cut tissue for use in IHC. When storing pre-cut tissue slides, it is typically done under refrigerated conditions (2 to 8°C), which can last for 2 to 3 years. However, the potential effects of storing at temperatures of -20°C with desiccant are not well-known in terms of tissue preservation. The best practice is to always use fresh cut tissue sections when possible.
Helpful?
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Is there information on what terminus was for CD56 MRQ-42?
1 answer-
Based on the information available, it seems that it is C-terminus.
Helpful?
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