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138R-2

Sigma-Aldrich

CD138 (EP201) Rabbit Monoclonal Primary Antibody

clone EP201, unconjugated, Cell Marque™

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP201, monoclonal

descrição

(For In Vitro Diagnostic Use in Select Regions (See Chart))

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

bottle of 1.0 mL predilute (138R-27)
bottle of 7.0 mL predilute (138R-28)
vial of 0.1 mL concentrate (138R-24)
vial of 0.5 mL concentrate (138R-25)
vial of 1.0 mL concentrate (138R-26)

fabricante/nome comercial

Cell Marque™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

Informações sobre genes

human ... SDC1(6382)

Descrição geral

CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6

Qualidade


IVD
IVD
IVD
RUO

Ligação

CD138 Positive Control Slides, Product No. 138S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview.
E Sabattini et al.
Pathologica, 102(3), 83-87 (2010-12-22)
M Chilosi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 12(12), 1101-1106 (2000-01-05)
Detection of abnormal numbers and/or distribution of bone marrow (BM) plasma cells (PCs) on trephine biopsies can be important in the differential diagnosis of multiple myeloma (MM) and other PC disorders. A variety of immunohistochemical markers can potentially improve the
A Sebestyén et al.
British journal of haematology, 104(2), 412-419 (1999-03-02)
Syndecan-1, an important transmembrane heparan sulphate proteoglycan is expressed in distinct stages of differentiation of normal lymphoid cells: in pre-B cells and Ig-producing plasma cells; however, its normal function, or presence in lymphoid malignancies, is still largely unknown. The expression
Fionnuala P O'Connell et al.
American journal of clinical pathology, 121(2), 254-263 (2004-02-27)
We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. In 91 bone marrow biopsies, CD138 reactivity was observed for nonneoplastic plasma cells, neoplastic plasma cells in multiple myeloma cases (43/43), and
Lluís Colomo et al.
The American journal of surgical pathology, 28(6), 736-747 (2004-05-29)
Plasmablastic lymphoma was initially described as a variant of diffuse large B-cell lymphoma (DLBCL) involving the oral cavity of HIV+ patients and characterized by immunoblastic morphology and a plasma cell phenotype. However, other lymphomas may exhibit similar morphologic and immunophenotypic
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