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Y0000878

Atropine

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

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About This Item

Fórmula empírica (Notação de Hill):
C17H23NO3
Número CAS:
51-55-8
Peso molecular:
289.37
Beilstein:
91260
Número MDL:
MFCD00022622
Código UNSPSC:
41116107
ID de substância PubChem:
329831200
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.

grau

pharmaceutical primary standard

família API

atropine

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

chave InChI

RKUNBYITZUJHSG-SPUOUPEWSA-N

Informações sobre genes

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Atropine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

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Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300 + H330

Classificações de perigo

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Baptiste Berton et al.
Pharmaceutics, 12(8) (2020-08-23)
Myopia is an ophthalmic condition affecting more than 1/5th of the world population, especially children. Low-dose atropine eyedrops have been shown to limit myopia evolution during treatment. However, there are currently no commercial industrial forms available and there is little
Incidence, pathophysiology, and treatment of complications during dobutamine-atropine stress echocardiography.
Marcel L Geleijnse et al.
Circulation, 121(15), 1756-1767 (2010-04-21)
D Poldermans et al.
European heart journal, 18 Suppl D, D86-D96 (1997-06-01)
Cardiac events in the peri-operative phase and late after non-cardiac vascular surgery are a major cause of morbidity and mortality. Numerous tests and diagnostic strategies--usually consisting of a combination of analysis of clinical risk factors and additional non-exercise dependent stress
Peter Jones et al.
Archives of disease in childhood, 97(2), 139-144 (2011-05-31)
Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction. Some induction drugs also induce bradycardia which may be accompanied
M M McCarron et al.
Pediatrics, 87(5), 694-700 (1991-05-01)
Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed. This overdose is primarily an opioid intoxication, occasionally associated with atropine toxicity. Only 6 of 36 children showed signs of atropine overdose (central nervous system
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