T176

4-Hidroxitamoxifeno

analytical standard, (E) and (Z) isomers (50:50)

• Sinônimo(s): 4-(1-[4-(Dimetilaminoetoxi)fenil]-2-fenil-1-butenil)fenol, 4-OHT, cis/trans-4-hidroxitamoxifeno
• Fórmula empírica (Notação de Hill): C₂₆H₂₉NO₂
• Número CAS: 68392-35-8
• Peso molecular: 387.51
• Código UNSPSC: 41116107
• ID de substância PubChem: 24899989
• NACRES: NA.24

Propriedades

• grau: analytical standard
• Nível de qualidade: 200
• Formulário: powder
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• solubilidade: ethanol: 20 mg/mL
• espectro de atividade do antibiótico: neoplastics
• aplicação(ões): forensics and toxicology; pharmaceutical (small molecule)
• Formato: neat
• Modo de ação: enzyme | inhibits
• cadeia de caracteres SMILES: CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
• InChI: 1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
• chave InChI: ZJLDABGSDWXVGE-BDSXMVAQSA-N
• Informações sobre genes: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) , IL6(3569) ; rat ... Ar(24208) , Esr1(24890) , Esr2(25149)

Descrição

Descrição geral

4-Hydroxytamoxifen is an antiestrogenic agent and one of the active metabolites of tamoxifen, formed upon its hydroxylation cytochrome P4502D6 (CYP2D6). Tamoxifen is used significantly in breast cancer as hormonal therapy.

Aplicação

The 4-Hydroxytamoxifen analytical standard can be used as follows:

• Determination of tamoxifen and its three metabolites from dried blood spot (DBS) discs by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
• Simultaneous estimation of tamoxifen, 4-hydroxytamoxifen, and endoxifen from DBS samples by UHPLC-MS/MS
• Development and validation of a non-aqueous capillary electrophoretic (NACE) method coupled with capacitively coupled contactless conductivity detection (C⁴D) to analyze tamoxifen and its three main metabolites after their liquid-liquid extraction (LLE) from human plasma samples obtained from breast cancer patients
• Multi-residue analysis of human plasma samples to quantify tamoxifen and its degradation products using the non-aqueous capillary electrophoretic (NACE) method combined with UV-detection
• Combined detection of tamoxifen and centchroman, along with their degradation products in human plasma samples by LC-ESI-MS/MS

Ações bioquímicas/fisiológicas

Metabólito do medicamento quimioterápico tamoxifeno, com uma atividade de agonista/antagonista de estrógeno mais potente que a do fármaco original. Também ativo como inibidor intramembranar da peroxidação lipídica.

Outras notas

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302 + H312 + H332,H315,H319,H361fd
• Declarações de precaução: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges