PHR1294

Chlorhexidine digluconate

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Chlorhexidine digluconate solution, 1,6-Bis(N⁵-[p-chlorophenyl]-N¹-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
• Número CAS: 18472-51-0
• Número MDL: MFCD00083599
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823285
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to Ph. Eur. C1510000/1520000; traceable to USP 1111001/1111103
• descrição: Chlorhexidine digluconate solution at approximately 20% in water
• família API: chlorhexidine
• Certificado de análise (CofA): current certificate can be downloaded
• aplicação(ões): pharmaceutical (small molecule)
• formato: single component solution
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
• InChI: 1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
• chave InChI: YZIYKJHYYHPJIB-UUPCJSQJSA-N

Descrição

Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Chlorhexidine digluconate may be used as a pharmaceutical reference standard for the determination of the analyte in eye drop formulations using capillary electrophoresis technique with contactless conductivity detection.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC0252 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informações de segurança

• Pictogramas: GHS05,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H318,H410
• Declarações de precaução: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Classificações de perigo: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable