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PHR1081

Supelco

Octisalate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

2-Ethylhexyl salicylate, Octisalate, Octyl salicylate

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About This Item

Fórmula linear:
(HO)C6H4CO2CH2CH(C2H5)(CH2)3CH3
Número CAS:
Peso molecular:
250.33
Beilstein:
2730664
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to USP 1477943

família API

octisalate

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refração

n20/D 1.502 (lit.)

pb

189-190 °C/21 mmHg (lit.)

densidade

1.014 g/mL at 25 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

CCCCC(CC)COC(=O)c1ccccc1O

InChI

1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

chave InChI

FMRHJJZUHUTGKE-UHFFFAOYSA-N

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Descrição geral

Octisalate is a sunscreen agent that acts as a UV filter for UVB (280-315 nm) radiation.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Octisalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical and sunscreen formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC0298 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Nº do produto
Descrição
Preços

Pictogramas

Environment

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Aquatic Chronic 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

323.6 °F - closed cup

Ponto de fulgor (°C)

162 °C - closed cup


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Certificados de análise (COA)

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Thin layer chromatography-spray mass spectrometry: a method for easy identification of synthesis products and UV filters from TLC aluminum foils
Himmelsbach M, et al.
Analytical and Bioanalytical Chemistry, 406(15), 3647-3656 (2014)
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USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 43(3), 3194-3194 (2018)
Development and Validation of RP-HPLC Method for Analysis of Four UV Filters in Sunscreen Products
Yousef AN, et al.
International Journal of Pharmaceutical Sciences Review and Research (2013)
K A Walters et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 35(12), 1219-1225 (1998-02-04)
The human skin penetration of [14C]octyl salicylate from two representative sunscreen vehicles was determined in vitro. 3H-sucrose was incorporated into all formulations and provided a marker for membrane integrity. When applied as a finite dose in an oil-in-water emulsion vehicle
P Clarys et al.
Journal of dermatological science, 27(2), 77-81 (2001-09-05)
Temperature influences the stratum corneum adsorption of several topically applied compounds. This study was designed to evaluate the influence of the temperature on the stratum corneum adsorption of 3 UV filters. The UV filters were solubilized in two vehicles, an

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