This is a product of the European Pharmacopoeia.
Please see the link below for additional product information, including the Certificate (Leaflet):
https://crs.edqm.eu/db/4DCGI/View=N1300000
N1300000
Noscapine
European Pharmacopoeia (EP) Reference Standard
Sinônimo(s):
(S,R)-Noscapine
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About This Item
Fórmula empírica (Notação de Hill):
C22H23NO7
Número CAS:
Peso molecular:
413.42
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
grau
pharmaceutical primary standard
família API
noscapine
fabricante/nome comercial
EDQM
pf
174-176 °C (lit.)
aplicação(ões)
pharmaceutical (small molecule)
Formato
neat
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
COc1ccc2C(OC(=O)c2c1OC)C3N(C)CCc4cc5OCOc5c(OC)c34
InChI
1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1
chave InChI
AKNNEGZIBPJZJG-MSOLQXFVSA-N
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Descrição geral
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Aplicação
Noscapine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Embalagem
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Outras notas
Sales restrictions may apply.
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Nº do produto
Descrição
Preços
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - STOT SE 3
Órgãos-alvo
Central nervous system
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Ramesh Chandra et al.
Current drug metabolism, 13(10), 1476-1483 (2012-05-11)
Noscapine, a tubulin binding anticancer agent undergoing Phase I/II clinical trials, inhibits tumor growth in nude mice bearing human xenografts of breast, lung, ovarian, brain, and prostrate origin. The analogues of noscapine like 9-bromonoscapine (EM011) are 5 to 10-fold more
Harpal Singh et al.
Current drug metabolism, 14(3), 351-360 (2012-09-01)
This review introduces the Noscapine, which is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer drug that causes cell cycle arrest and induces apoptosis in cancer cells both
Melissa M Gajewski et al.
Pharmaceutical research, 29(11), 2985-2993 (2012-06-27)
This article reviews the recent findings regarding the binding sites, binding modes and binding affinities of three novel antimitotic drugs peloruside, laulimalide and noscapine with respect to tubulin as the target of their action. These natural compounds are shown to
Noscapine may increase the effect of warfarin.
Staffan Ohlsson et al.
British journal of clinical pharmacology, 65(2), 277-278 (2007-09-19)
Milad Iranshahy et al.
Journal of Asian natural products research, 16(12), 1148-1152 (2014-11-02)
A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The structures of compounds were determined by 1D/2D NMR and MS data. All
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