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D2950000

Disulfiram

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Tetraethylthiuram disulfide, Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Fórmula linear:
(C2H5)2NCSS2CSN(C2H5)2
Número CAS:
97-77-8
Peso molecular:
296.54
Beilstein:
1712560
Número CE:
202-607-8
Número MDL:
MFCD00009048
Código UNSPSC:
41116107
ID de substância PubChem:
329798762
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

disulfiram

fabricante/nome comercial

EDQM

pf

69-71 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

chave InChI

AUZONCFQVSMFAP-UHFFFAOYSA-N

Informações sobre genes

human ... ALDH2(217)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Alcohol dehydrogenase inhibitor.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

Nº do produto
Descrição
Preços

Palavra indicadora

Warning

Frases de perigo

H302,H317,H373,H410

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Pier Paolo Pani et al.
The Cochrane database of systematic reviews, (1)(1), CD007024-CD007024 (2010-01-22)
Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development. To evaluate the efficacy and the acceptability of disulfiram for cocaine dependence. We searched: PubMed, EMBASE, CINAHL
Charlotte H Jørgensen et al.
Alcoholism, clinical and experimental research, 35(10), 1749-1758 (2011-05-28)
Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The
Boris Cvek et al.
Drug discovery today, 13(15-16), 716-722 (2008-06-27)
The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used clinically. This strategy is time-consuming and expensive. Recent studies have disclosed a surprising, but mechanistically consistent, anticancer
Noriaki Nagai et al.
Toxicology, 315, 55-64 (2013-08-15)
Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42
Joanna Triscott et al.
Oncotarget, 3(10), 1112-1123 (2012-10-11)
Glioblastomas (GBM) are associated with high rates of relapse. These brain tumors are often resistant to chemotherapies like temozolomide (TMZ) and there are very few treatment options available to patients. We recently reported that polo-like kinase-1 (PLK1) is associated with
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