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C0410000

Canrenone

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713

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About This Item

Fórmula empírica (Notação de Hill):
C22H28O3
Número CAS:
976-71-6
Peso molecular:
340.46
Número MDL:
MFCD00071735
Código UNSPSC:
41116107
ID de substância PubChem:
329774785
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.

grau

pharmaceutical primary standard

família API

canrenone

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O

InChI

1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1

chave InChI

UJVLDDZCTMKXJK-WNHSNXHDSA-N

Informações sobre genes

human ... NR3C2(4306)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Canrenone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Health hazardEnvironment
GHS08,GHS09

Palavra indicadora

Warning

Frases de perigo

H351,H411

Declarações de precaução

P201 - P273 - P308 + P313

Classificações de perigo

Aquatic Chronic 2 - Carc. 2 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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Jiang Tian et al.
Hypertension (Dallas, Tex. : 1979), 54(6), 1313-1320 (2009-11-04)
Spironolactone has been noted to attenuate cardiac fibrosis. We have observed that the cardiotonic steroid marinobufagenin plays an important role in the diastolic dysfunction and cardiac fibrosis seen with experimental renal failure. We performed the following studies to determine whether
Da-Ming Huang et al.
Journal of biomedicine & biotechnology, 2011, 917232-917232 (2011-12-29)
A procedure for simultaneous identification and quantification of canrenone and its biotransformed product 11-α-hydroxy-canrenone by high-performance liquid chromatography with ultraviolet detector (HPLC-UVD) and mass spectrometry (LC-MS) methods was proposed. The optimal determination variables on the HPLC-UVD or LC-MS coupled with
Alessandro Boccanelli et al.
Journal of cardiovascular medicine (Hagerstown, Md.), 8(9), 683-691 (2007-08-19)
Excess aldosterone activity contributes to the pathogenesis and progression of heart failure (HF). Aldosterone antagonists improve clinical outcome in patients with severe HF or left ventricular (LV) dysfunction after myocardial infarction, but knowledge of their impact in mild chronic HF
Federico Bilotta et al.
Neurocritical care, 16(2), 280-285 (2011-11-22)
Mannitol therapy to treat cerebral edema induces osmotic diuresis and electrolyte loss. In neurocritical care patients, potassium is the electrolyte that most often needs replacement. Objective of this study was to evaluate the effects of adding potassium sparing diuretic (canrenone)
Maysa Faisal Suyagh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(9-10), 769-776 (2010-02-16)
A selective and sensitive liquid chromatography (LC)-atmospheric pressure chemical ionisation (APCI)-mass spectroscopic (MS) assay of canrenone has been developed and validated employing Dried Blood Spots (DBS) as the sample collection medium. DBS samples were prepared by applying 30 microl of
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