96408
N-(2-Phenylacetyl)glycine
analytical standard
Sinônimo(s):
2-(2-Phenylacetamido)acetic acid, 2-Phenylacetyl glycine, NSC 408424, NSC 92778, Phenaceturic acid, Phenacetylglycine
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About This Item
Fórmula empírica (Notação de Hill):
C10H11NO3
Número CAS:
Peso molecular:
193.20
Beilstein:
1107116
Número MDL:
Código UNSPSC:
12352209
ID de substância PubChem:
NACRES:
NA.24
Produtos recomendados
grau
analytical standard
Nível de qualidade
Ensaio
≥98.0% (HPLC)
prazo de validade
limited shelf life, expiry date on the label
aplicação(ões)
clinical testing
formato
neat
temperatura de armazenamento
2-8°C
InChI
1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)
chave InChI
UTYVDVLMYQPLQB-UHFFFAOYSA-N
Ações bioquímicas/fisiológicas
Phenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acylglycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Phenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis. Urinary PAG is elevated in animals exhibiting abnormal phospholipid accumulation in many tissues and may thus be useful as a surrogate biomarker for phospholipidosis. The presence of phenylacetylglycine in urine has been confirmed for dogs, rats and mice. However, the presence of this compound in human urine is controversial. GC-MS studies have not found this compound while NMR studies claimed to have identified it , It appears that phenylacetylglycine may sometimes be mistaken for phenylacetylglutamine via NMR.
Produtos recomendados
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Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Amiodarone was given to male Sprague-Dawley rats at a dose of 150 mg kg(-1) day(-1) for 7 consecutive days to induce phospholipidosis in the lungs of treated rats. Amiodarone was given alone or concurrently with phenobarbitone. Animals given amiodarone had
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The Journal of veterinary medical science, 57(2), 205-211 (1995-04-01)
After the urine was treated with urease, lyophilized, and trimethylsilylated, it was examined for metabolic profiles in Dalmatian dogs and Shetland sheepdogs by gas chromatography-mass spectrometry (GC/MS), which simultaneously analyzes organic acids, amino acids, sugars, sugar alcohols, purine and pyrimidine
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