916625

tert-Butyl 4-(3-(2-aminoethyl)phenyl)piperidine-1-carboxylate

≥95%

• Sinônimo(s): Semi-flexible linker for PROTAC^® development
• Fórmula empírica (Notação de Hill): C₁₈H₂₈N₂O₂
• Número CAS: 1402672-70-1
• Peso molecular: 304.43
• Código UNSPSC: 12352116

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95%
• forma: liquid
• adequação da reação: reagent type: linker
• grupo funcional: Boc; amine
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(N(CC1)CCC1C2=CC(CCN)=CC=C2)OC(C)(C)C

Descrição

Aplicação

tert-Butyl 4-(3-(2-aminoethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Outras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable