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Supelco

Thiamphenicol

analytical standard

Sinônimo(s):

D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide

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About This Item

Fórmula empírica (Notação de Hill):
C12H15Cl2NO5S
Número CAS:
Peso molecular:
356.22
Beilstein:
2819542
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

Ensaio

≥98.0% (HPLC)

prazo de validade

limited shelf life, expiry date on the label

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

solubilidade

ethanol: 50 mg/mL, clear, colorless to faintly yellow

aplicação(ões)

clinical

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl

InChI

1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1

chave InChI

OTVAEFIXJLOWRX-NXEZZACHSA-N

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Descrição geral

Chemical structure: sulfonamide
Thiamphenicol is an analog of a broad spectrum antibiotic, chloramphenicol. It shows therapeutic effects in respiratory infections, venereal diseases and bacterial prostatitis.

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Thiamphenicol may be used as a reference standard in the determination of thiamphenicol in honey using dispersive liquid-liquid microextraction (DLLME) coupled with high-performance liquid chromatography-variable wavelength detector (HPLC-VWD).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Certificados de análise (COA)

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Dispersive liquid--liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey
Chen H, et al.
Analytica Chimica Acta, 632(1), 80-85 (2009)
Chloramphenicol and thiamphenicol.
J Fuglesang et al.
Antibiotics and chemotherapy, 31, 1-21 (1982-01-01)
[Chloramphenicol and thiamphenicol].
L Mariani
La Clinica terapeutica, 86(3), 195-218 (1978-08-15)
D Malvy et al.
Intensive care medicine, 18(8), 485-487 (1992-01-01)
A 27-year-old woman, without compromised immunodefenses, experienced a Listeria meningoencephalitis, with brainstem symptoms. The identified agent exhibited poor susceptibility to usual effective antibiotics, except for penicillins. Knowledge of past history of an allergic reaction to beta-lactam antibiotics lead to appropriate
[Toxicity of chloramphenicol and thiamphenicol (CAP and TAP)].
G Keiser
Haematology and blood transfusion, 21, 179-195 (1978-01-01)

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