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Documentos Principais

10171832001

Roche

Aldehyde Dehydrogenase

from yeast

Sinônimo(s):

Aldehyde dehydrogenase

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About This Item

Número da licença da enzima:
Código UNSPSC:
12352204

fonte biológica

yeast

Nível de qualidade

Formulário

lyophilized

atividade específica

~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)

embalagem

pkg of 250 U

fabricante/nome comercial

Roche

pH ideal

8.75

doença(s) relevante(s)

cancer

temperatura de armazenamento

2-8°C

Descrição geral

Aldehyde dehydrogenase (ALDH) is a soluble enzyme and its activity depends on potassium ions and cysteine. The family of ALDH comprises of 19 genes in human. ALDH gene is expressed in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. ALDH is a component of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) recycling systems.

Aplicação

Aldehyde Dehydrogenase has been used to evaluate fiber-optic biosensors for measurement of acetaldehyde (AcH) in liquid phase (AcH biosensor).

Ações bioquímicas/fisiológicas

Aldehyde dehydrogenase (ALDH) regulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene are associated with Sjogren Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH takes part in the oxidation of aldehydes to acids. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.

Qualidade

Contaminants: <0.01% “NADH oxidase”, ADH, and LDH each

forma física

Enzyme is stabilized with potassium phosphate buffer, pH approximately 6.

Outras notas

For life science research only. Not for use in diagnostic procedures.

Pictogramas

Exclamation markHealth hazard

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Acute Tox. 4 Inhalation - STOT RE 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash


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Visite a Biblioteca de Documentos

Yeast Aldehyde Dehydrogenase II. PROPERTIES OF THE HOMOGENEOUS ENZYME PREPARATIONS
Charles R. Steinman and WILLIAM B. JAKOBY
The Journal of Biological Chemistry, 243(4), 730-734 (1965)
Kenta Iitani et al.
Sensors (Basel, Switzerland), 23(13) (2023-07-14)
The molecule 2-nonenal is renowned as the origin of unpleasant human aging-related body odor that can potentially indicate age-related metabolic changes. Most 2-nonenal measurements rely on chromatographic analytical systems, which pose challenges in terms of daily usage and the ability
Improved sensitivity of acetaldehyde biosensor by detecting ADH reverse reaction-mediated NADH fluoro-quenching for wine evaluation
Iitani K, et al.
ACS sensors, 2(7), 940-946 (2017)
Yeast aldehyde dehydrogenase.
S BLACK
Archives of biochemistry and biophysics, 34(1), 86-97 (1951-11-01)
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
Chen CH, et al.
Science (New York, N.Y.), 321(5895), 1493-1495 (2008)

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