MABS460

Anti-FGF23 Antibody, clone 278-2

clone 278-2, from mouse

• Sinônimo(s): Fibroblast growth factor 23, FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, Fibroblast growth factor 23 N-terminal peptide, Fibroblast growth factor 23 C-terminal peptide
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 278-2, monoclonal
• reatividade de espécies: human
• técnica(s): flow cytometry: suitable; western blot: suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_065689
• nº de adesão UniProt: Q9GZV9
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... FGF23(8074)

Descrição

Descrição geral

Fibroblast growth factor 23 (FGF-23) is also called Phosphatonin and Tumor-derived hypophosphatemia-inducing factor. FGF-23 belongs to the heparin-binding growth factors family and has several important functions including: regulation of phosphate homeostasis, inhibition of renal tubular phosphate transport, upregulation of EGR1 expression, regulation of vitamin-D metabolism, and negative regulation of osteoblast differentiation and matrix mineralization. FGF-23 is expressed in osteogenic cells, adult trabecular bone, osteocytes and flattened bone-lining cells (inactive osteoblasts). Defects in FGF23 can lead to autosomal dominant hypophosphataemic rickets (ADHR) and hyperphosphatemic familial tumoral calcinosis (HFTC).

Imunogênio

Corresponding to human FGF23.

Aplicação

Anti-FGF23 Antibody, clone 278-2 is a mouse monoclonal antibody & validated for use in western blotting.

Flow Cytometry Analysis: 2 µg from a representative lot detected FGF23 in Jurkat and human PMBC cells.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Qualidade

Evaluated by Western Blotting in human salivary gland tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected FGF23 in 10 µg of human salivary gland tissue lysate.

Descrição-alvo

~25 kDa observed

forma física

Format: Purified

Protein A purified

Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Human salivary gland tissue lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable