MABN349

Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1

clone 1B12.1, 0.5 mg/mL, from mouse

• Sinônimo(s): Synaptotagmin-12, Synaptotagmin XII, SytXII, Synaptotagmin-12 (SYT12)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 1B12.1, monoclonal
• reatividade de espécies: human, rat
• concentração: 0.5 mg/mL
• técnica(s): western blot: suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_001171351
• nº de adesão UniProt: Q8IV01
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SYT12(91683)

Descrição

Descrição geral

Synaptotagmin-12 (SYT12) , also known as Synaptotagmin-12, Synaptotagmin XII, SytXII, and encoded by the gene SYT12, is an important protein involved in calcium dependent exocytosis of secretory vesicles through calcium and phospholipid binding to the C2 domain and Synaptotagmin-12 may serve as calcium sensors in the process of vesicular trafficking and exocytosis. Synaptotagmin-12 is a synaptic vesicle phosophoprotein that modulates spontaneous neurotransmitter release, but unlike other family members Synaptotagmin-12 differs from classical synaptotagmins in that it does not bind Ca(2+). In synaptic vesicles, synaptotagmin-12 forms a complex with synaptotagmin-1 that prevents synaptotagmin-1 from interacting with SNARE complexes. Synaptotagmin-12 also is an abundant synaptic vesicle protein that is important in LTP transmission. For instance, its phosphorylation by cAMP Protein Kinase is necessary for hippocampal mossy fiber LTP.

Imunogênio

Epitope: Cytoplasmic domain

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Synaptotagmin-12 (SYT12).

Aplicação

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 is validated for use in Western Blotting for the detection of Synaptotagmin-12 (SYT12).

Qualidade

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Synaptotagmin-12 (SYT12) in 200 µg of rat brain tissue lysate.

Descrição-alvo

~ 47 kDa observed

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1