ABE559

Anti-Xrcc1 Antibody

serum, from rabbit

• Sinônimo(s): DNA repair protein XRCC1, X-ray repair cross-complementing protein 1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: serum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• reatividade de espécies: mouse, human, rat
• técnica(s): immunoprecipitation (IP): suitable; western blot: suitable
• nº de adesão NCBI: NP_033558
• nº de adesão UniProt: Q60596
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... XRCC1(7515)

Descrição

Descrição geral

DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. XRCC1 interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells.

Imunogênio

Linear peptide corresponding to mouse Xrcc1.

Aplicação

Anti-Xrcc1 Antibody is a highly specific rabbit polyclonal antibody, that targets XRCC1 & has been tested in western blotting & IP.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Xrcc1 in HepG2 cell lysate.

Western Blotting Analysis: A representative lot from an independent laboratory detected Xrcc1 in HEK293T, HeLa and MEF cell lysates (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.).

Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Xrcc1 in HEK293T, HeLa and MEF cell lysates (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.).

Qualidade

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Xrcc1 in 10 µg of Jurkat cell lysate.

Descrição-alvo

~80 kDa observed. The molecular weight of this protein is calculated at 69 kDa; however it has been observed at ~80 kDa (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.). An uncharacterized band may be observed at ~51 kDa in some cell lysates.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1