AB5038P
Anti-α-Synuclein (SNCA) Antibody
CHEMICON®, rabbit polyclonal
Sinônimo(s):
Anti-NACP, Anti-PARK4, Anti-PD1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Preço e disponibilidade não estão disponíveis no momento.
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Nome do produto
Anti-Synuclein α Antibody, Chemicon®, from rabbit
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
purificado por
affinity chromatography
reatividade de espécies
rat, human
fabricante/nome comercial
Chemicon®
técnica(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... SNCA(6622)
Descrição geral
alpha -Synuclein is a small (140-amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer′s Disease (AD). alpha -Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including alpha-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).
Especificidade
Recognizes Alpha-synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB5038 with beta-synuclein to a minimum. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.
Imunogênio
Human alpha-synuclein residues 111-131 coupled to KLH. The peptide sequence is N-GILEDMPVDPDNEAYEMPSEEC-C. This peptide is available for use in blocking studies (Cat. No. AG239).
Aplicação
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
This Anti-Synuclein Antibody, α is validated for use in IH(P), WB for the detection of Synuclein.
Western blot: 1:1000-1:2000
Immunohistochemistry: 1:1000-1:2000 on paraffin sections, 1:4000-1:12,000 on frozen sections..
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:1000-1:2000 on paraffin sections, 1:4000-1:12,000 on frozen sections..
Optimal working dilutions must be determined by end user.
Descrição-alvo
14-19 kDa
Ligação
Replaces: 04-1053
forma física
Affinity Purified immunoglobulin. Lyophilized, no preservatives. Reconstitute with 20 μL of sterile distilled water. Centrifuge to remove any residue.
ImmunoAffinity Purified
Armazenamento e estabilidade
Maintain at -20 in undiluted aliquots for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Nota de análise
Control
Brain tissue
Brain tissue
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Dominique Bétemps et al.
Acta neuropathologica communications, 2, 29-29 (2014-03-15)
The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson's disease (PD) or dementia with Lewy bodies (DLB), the intraneuronal deposition of aggregated alpha-synuclein (αS) is a
Raffaella Rusconi et al.
Aging cell, 17(2) (2018-02-01)
Increased expression of α-synuclein can initiate its long-distance brain transfer, representing a potential mechanism for pathology spreading in age-related synucleinopathies, such as Parkinson's disease. In this study, the effects of overexpression-induced α-synuclein transfer were assessed over a 1-year period after
Michael Helwig et al.
Brain : a journal of neurology, 139(Pt 3), 856-870 (2016-01-01)
Aggregation and neuron-to-neuron transmission are attributes of α-synuclein relevant to its pathogenetic role in human synucleinopathies such as Parkinson's disease. Intraparenchymal injections of fibrillar α-synuclein trigger widespread propagation of amyloidogenic protein species via mechanisms that require expression of endogenous α-synuclein
Christopher Gibbons et al.
Neurology, 100(15), e1529-e1539 (2023-01-20)
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder caused by the abnormal accumulation of α-synuclein in the nervous system. Clinical features include autonomic and motor dysfunction, which overlap with those of Parkinson disease (PD), particularly at early disease stages.
Juan C Vizcarra et al.
Free neuropathology, 4 (2023-06-22)
The collection of post-mortem brain tissue has been a core function of the Alzheimer Disease Research Center's (ADRCs) network located within the United States since its inception. Individual brain banks and centers follow detailed protocols to record, store, and manage
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