8.14727

Brij^® 58

for synthesis

• Sinônimo(s): Brij^® 58, Polyoxyethylene (20) cetylether, Polyethyleneglycol (20) cetylether
• Fórmula linear: HO-(CH₂CH₂O)_n-(CH₂)₁₅-CH₃
• Número CAS: 9004-95-9
• Número MDL: MFCD00080892
• Código UNSPSC: 12352104
• Número do índice EC: 500-014-1
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• forma: solid
• potência: 2500 mg/kg LD₅₀, oral (Rat)
• pf: 38-42 °C
• temperatura de transição: flash point >149 °C
• temperatura de armazenamento: 2-30°C
• InChI: 1S/C56H114O21/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-58-19-21-60-23-25-62-27-29-64-31-33-66-35-37-68-39-41-70-43-45-72-47-49-74-51-53-76-55-56-77-54-52-75-50-48-73-46-44-71-42-40-69-38-36-67-34-32-65-30-28-63-26-24-61-22-20-59-18-16-57/h57H,2-56H2,1H3
• chave InChI: NLMKTBGFQGKQEV-UHFFFAOYSA-N

Descrição

Aplicação

• Potential Activity of Micafungin and Amphotericin B Co-Encapsulated in Nanoemulsion against Systemic Candida auris Infection in a Mice Model.: This study investigates the use of Brij® 58 in formulating a nanoemulsion to enhance the efficacy of micafungin and amphotericin B against systemic Candida auris infections in mice. The results suggest significant improvements in drug delivery and antifungal activity (Marena et al., 2024).
• Encapsulation of Pure Water-Stable Perovskite Nanocrystals (PNCs) into Biological Environment-Stable PNCs for Cell Imaging.: This research highlights the role of Brij® 58 in stabilizing perovskite nanocrystals, enhancing their stability and applicability in biological environments for cell imaging purposes (Zheng et al., 2024).
• Improving Drug Delivery on Candida Albicans Using Geraniol Nanoemulsion.: This paper discusses the use of Brij® 58 in geraniol nanoemulsions to enhance drug delivery against Candida albicans, showing improved antifungal effectiveness and stability (Silva Pontes et al., 2023).
• Combined Effect of Shaking Orbit and Vial Orientation on the Agitation-Induced Aggregation of Proteins.: Brij® 58 is utilized in this study to prevent protein aggregation in pharmaceutical formulations during agitation, highlighting its importance in maintaining protein stability (Dasnoy et al., 2024).

Nota de análise

Hydroxyl value: 45 - 60
Water (K. F.): ≤ 3.0 %
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Informações legais

Brij is a registered trademark of Croda International PLC

Informações de segurança

• Pictogramas: GHS09
• Frases de perigo: H411
• Declarações de precaução: P273 - P391 - P501
• Classificações de perigo: Aquatic Chronic 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 302.0 °F - closed cup
• Ponto de fulgor (°C): 150 °C - closed cup