557404-M

RNA Polymerase III Inhibitor

InSolution, ≥97%

• Sinônimo(s): InSolution RNA Polymerase III Inhibitor, 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide
• Fórmula empírica (Notação de Hill): C₁₉H₁₅Cl₂N₃O₂S₂
• Número CAS: 577784-91-9
• Peso molecular: 452.38
• Número MDL: MFCD00112663
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: liquid
• potência: 27 μM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• temperatura de armazenamento: −70°C
• cadeia de caracteres SMILES: [S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl
• InChI: 1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
• chave InChI: BVBDTTLISMIOJY-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC₅₀ = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available.

Ações bioquímicas/fisiológicas

Primary Target
RNA Polymerase III

Advertência

Toxicity: Standard Handling (A)

forma física

A 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO.

Reconstituição

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Outras notas

Wu, L., et al. 2003. Euk. Cell2, 256.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 188.6 °F - closed cup - (refers to pure substance)
• Ponto de fulgor (°C): 87 °C - closed cup - (refers to pure substance)