5.04905

Memantine Hydrochloride

• Sinônimo(s): Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride
• Fórmula empírica (Notação de Hill): C₁₂H₂₁N · xHCl
• Número CAS: 41100-52-1
• Peso molecular: 179.30 (free base basis)
• Número MDL: MFCD00214336
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: H₂O: 100 mM
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [Cl-].[N+H3]C21CC3(CC(C2)(CC(C1)C3)C)C
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
• chave InChI: LDDHMLJTFXJGPI-UHFFFAOYSA-N

Descrição

Descrição geral

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC₅₀ = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).

Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

Ações bioquímicas/fisiológicas

Primary Target
NMDA receptors

Target IC₅₀: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.
Anand, A., et al. 2012. Bipolar Dis.14, 64.
Lopes, P., et al. 2013. Brain and Behavior.3, 67.
Howard, R., et al. 2012. New Eng. J. Med.366, 893.
Parsons, G., et al. 1999. Neuropharmacol.38, 735.
Lee, G., et al. 2012. Psychiatry Investig.9, 166.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable