401116

Human IgG, Fab Fragment, Plasma

• Sinônimo(s): IgG Fab fragment
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Ensaio: ≥95% (SDS-PAGE)
• Nível de qualidade: 100
• Formulário: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• solubilidade: sterile distilled water: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified

Descrição

Descrição geral

Immunoglobulin G (IgG) is the most crucial glycoprotein antibody.[1] It has the longest serum half-life compared to other immunoglobulins.[1] IgG is present in human serum[2][1] and also identified in the bloodstream.[1] It contains four polypeptide chains, wherein the light and heavy chains are linked by disulfide bonds.[2]

Aplicação

Human IgG, Fab Fragment, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).[3]

Ações bioquímicas/fisiológicas

Immunoglobulin G (IgG) initiates the classical pathway of the complement system and eliminates virus particles and toxins.[2][1] It controls antibody-dependent cell-mediated cytotoxicity (ADCC)[2] and might be correlated to allergy.[4] Digestion of IgG by papain generates fragment antigen-binding (Fab) whereas pepsin digestion of IgG releases crystallizable (Fc) fragment and a single dimeric F(ab)₂.[1]  Maternal IgG is transferred to the fetus via the placenta and is crucial for the immune defense of the neonate against infections.[5] IgG levels in severe acute respiratory syndrome coronavirus (SARS-CoV)2 infected patients may be useful to understand the severity and prognosis of coronavirus disease 2019 (COVID-19).[6]  

Advertência

Toxicity: Standard Handling (A)

forma física

In 150 mM NaCl, 20 mM sodium phosphate buffer, 0.05% NaN₃, pH 7.4.

Nota de preparo

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies of HIV and HCV.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable