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Documentos Principais

317240

Sigma-Aldrich

Metformin

≥97% (titration), solid, AMPK signaling activator, Calbiochem®

Sinônimo(s):

Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII

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About This Item

Fórmula empírica (Notação de Hill):
C4H11N5 · xHCl
Número CAS:
1115-70-4
Peso molecular:
129.16 (free base basis)
Número MDL:
MFCD00012582
Código UNSPSC:
12352200
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

Metformin, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

Nível de qualidade

100

descrição

Merck USA index - 14, 5938

Ensaio

≥97% (titration)

Formulário

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
desiccated (hygroscopic)

cor

white

solubilidade

water: 50 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

10-30°C

cadeia de caracteres SMILES

Cl.N(C)(C)C(=N\C(=N\[H])\N)N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

chave InChI

OETHQSJEHLVLGH-UHFFFAOYSA-N

Descrição geral

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

Ações bioquímicas/fisiológicas

Cell permeable: no
Primary Target
AMP-activated protein kinase (AMPK)
Product does not compete with ATP.
Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Irritant (B)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H319

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Questions

1–2 of 2 Questions  

  1. What is the solubility of Metformin (Cat#317240) in DMSO?

    1 answer

    1. The substance dissolves in DMSO at concentrations of up to 8 mg/ml.

      Helpful?

  2. is metformin accociated with paracitic worms?

    1 answer

    1. There have been studies published regarding the efficacy of Metformin against various parasites. Please see the link below to review one such study of Echinococcisis. Note that this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321462/

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