203702
Brain Derived Neurotrophic Factor, Human, Recombinant, E. coli
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About This Item
Código UNSPSC:
12352202
Produtos recomendados
Ensaio
≥97% (HPLC)
Nível de qualidade
forma
lyophilized
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
desiccated
Condições de expedição
ambient
temperatura de armazenamento
−20°C
Descrição geral
Recombinant, human brain drived neurotrophic factor expressed in E. coli. Promotes survival and growth of neurons in the central nervous system. Sequence analysis indicates that brain derived neurotrophic factor is structurally and functionally related to nerve growth factor. mRNA for brain derived neurotrophic factor is found predominantly in the central nervous system, whereas mRNA for nerve growth factor is also found in many non-CNS tissues.
Recombinant, human brain drived neurotrophic factor expressed in E. coli. Promotes survival and growth of neurons. Structurally and functionally related to nerve growth factor. Its actions are mediated via the TrkB receptor.
Ações bioquímicas/fisiológicas
Supports survival of rat basal forebrain primary septal cultured neurons. Induces choline acetyltransferase (EC₅₀ = 50 ng/ml)
Advertência
Toxicity: Standard Handling (A)
Reconstituição
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Reconstitute to a concentration of ≥10 µg/ml with sterile distilled H₂O or aqueous buffers. For more dilute solutions, add a stabilizing protein such as 0.1% BSA or HSA.
Outras notas
Erickson, J.T., et al. 1996. J. Neurosci. 16, 5361.
Leibrock, J., et al. 1989. Nature341, 149.
Leibrock, J., et al. 1989. Nature341, 149.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
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S M Mooney et al.
Neuroscience, 179, 256-266 (2011-02-01)
A second wave of neuronal generation occurs in the ventrobasal nucleus of the rat thalamus (VB) during the first three postnatal weeks. The present study tested the hypotheses (1) that postnatal neurogenesis in the VB is neurotrophin-regulated and (2) that
Christophe Heinrich et al.
Nature protocols, 6(2), 214-228 (2011-02-05)
Instructing glial cells to generate neurons may prove to be a strategy to replace neurons that have degenerated. Here, we describe a robust protocol for the efficient in vitro conversion of postnatal astroglia from the mouse cerebral cortex into functional
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