178488

Apoptosis Inhibitor

The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinônimo(s): Apoptosis Inhibitor, M50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
• Fórmula empírica (Notação de Hill): C₁₃H₁₆O₄
• Número CAS: 54135-60-3
• Peso molecular: 236.26
• Número MDL: MFCD01103582
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated
• cor: off-white
• solubilidade: DMSO: 100 mg/mL; ethanol: 20 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1CCCC(=O)C1CC2C(=O)CCCC2=O
• InChI: 1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2
• chave InChI: ILUMEPMGPCKGHH-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable inhibitor of apoptosis induction (IC₅₀ = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.

A cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC₅₀ = 67 µg/ml) and etoposide-stimulated U937 cells (IC₅₀ = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC₅₀ = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
apoptosis induction

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Tsuda, T., et al. 2001. Eur. J. Pharmacol.433, 37.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable