05-1109
Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01
clone C-PEP-01, from mouse
Sinônimo(s):
CD220 antigen, insulin receptor
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
C-PEP-01, monoclonal
reatividade de espécies
human
técnica(s)
immunohistochemistry: suitable (paraffin)
Isotipo
IgG1
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... INS(3630)
Descrição geral
Pro-Insulin consists of the three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the Insulin molecule). From every molecule of Pro-Insulin, one molecule of Insulin plus one molecule of C-peptide are produced. C-peptide is released into the blood stream in equal amounts to Insulin.
Especificidade
No cross-reactivity with Insulin or other peptide hormones or proteins was observed.
The antibody C-PEP-01 reacts specifically with C-peptide, a part of the Pro-insulin molecule.
Imunogênio
Synthetic C-peptide of human pro-insulin conjugated to bovine serum albumin.
Aplicação
Research Category
Signaling
Signaling
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
This Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 is validated for use in IH(P) for the detection of Pro-Insulin C-Peptide.
Qualidade
Evaluated by Immunohistochemistry in normal human pancreas.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.
Descrição-alvo
Approx. 12 kDa
Ligação
Replaces: CBL94
forma física
Format: Purified
Mouse monoclonal IgG1 in phosphate buffered saline, pH7.4, and 15 mM sodium azide.
Sequential precipitation with caprylic acid and ammonium sulfate.
Armazenamento e estabilidade
Store at 2-8°C and use within 1 year from date of receipt.
Nota de análise
Control
Human normal pancreas tissue
Human normal pancreas tissue
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Mahmoud M Gabr et al.
Scientific reports, 14(1), 17844-17844 (2024-08-02)
This study was to determine whether extracellular vesicles (EVs) derived from insulin-producing cells (IPCs) can modulate naïve mesenchymal stromal cells (MSCs) to become insulin-secreting. MSCs were isolated from human adipose tissue. The cells were then differentiated to generate IPCs by
Mohammad Massumi et al.
PloS one, 11(10), e0164457-e0164457 (2016-10-19)
The ability to yield glucose-responsive pancreatic beta-cells from human pluripotent stem cells in vitro will facilitate the development of the cell replacement therapies for the treatment of Type 1 Diabetes. Here, through the sequential in vitro targeting of selected signaling
Sapna Puri et al.
Nature communications, 9(1), 485-485 (2018-02-06)
Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In contrast, proliferation is robust in neonatal β cells that are functionally
Haiqing Hua et al.
The Journal of clinical investigation, 123(7), 3146-3153 (2013-06-20)
Diabetes is a disorder characterized by loss of β cell mass and/or β cell function, leading to deficiency of insulin relative to metabolic need. To determine whether stem cell-derived β cells recapitulate molecular-physiological phenotypes of a diabetic subject, we generated
Sunghee Chai et al.
Human gene therapy, 33(15-16), 789-800 (2022-03-18)
Diabetes mellitus, caused by loss or dysfunction of the insulin-producing beta cells of the pancreas, is a promising target for recombinant adeno-associated virus (rAAV)-mediated gene therapy. To target potential therapeutic payloads specifically to beta cells, a cell type-specific expression control
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