Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos

N-005

Supelco

Norcodeine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C17H19NO3
Número CAS:
467-15-2
Peso molecular:
285.34
Número CE:
200-659-6
Número MDL:
MFCD00069317
Código UNSPSC:
41116107
ID de substância PubChem:
329818393
NACRES:
NA.24

grau

certified reference material

forma

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentração

1.0 mg/mL in methanol

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

forensics and toxicology

formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

COc1ccc2C[C@H]3NCC[C@@]45[C@@H](Oc1c24)[C@@H](O)C=C[C@@H]35

InChI

1S/C17H19NO3/c1-20-13-5-2-9-8-11-10-3-4-12(19)16-17(10,6-7-18-11)14(9)15(13)21-16/h2-5,10-12,16,18-19H,6-8H2,1H3/t10-,11+,12-,16-,17-/m0/s1

chave InChI

HKOIXWVRNLGFOR-KOFBORESSA-N

Categorias relacionadas

Descrição geral

Norcodeine is a primary urinary metabolite of codeine. Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. This certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications from urine drug testing and pain prescription monitoring to clinical toxicology and forensic analysis.

Aplicação

  • Pharmacokinetics and nociceptive effects of codeine in horses: A study conducted by Knych HK et al., investigated the pharmacokinetics and the effects on thermal nociception in horses following the administration of codeine. This research provides valuable data for understanding how opioid metabolites like norcodeine behave in non-human subjects, aiding in veterinary pharmacological applications (Knych et al., 2022).
  • Opioid metabolite analysis in forensic toxicology: Jakobsson G and colleagues developed a method using LC-MS/MS to analyze heroin-related compounds, including norcodeine, in postmortem samples. This research is crucial for forensic investigations, providing detailed insights into the metabolite profiles that can assist in the detection and analysis of opioid abuse cases (Jakobsson et al., 2021).
  • Analysis of opioid metabolites in forensic cases: Feliu C et al. presented a technique for quantifying various opioids and their derivatives, such as norcodeine, in whole blood using liquid chromatography-high-resolution mass spectrometry. This method is significant for forensic science, contributing to the accurate assessment of substances involved in fatal cases (Feliu et al., 2020).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

produto relacionado

Nº do produto
Descrição
Preços

C-006

Codeine solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-053

6-Acetylcodeine solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

C-005

Codeine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-007

Codeine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-015

Codeine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-040

Codeine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-041

Codeine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

C-087

Codeine-6-β-D-glucuronide solution, 100 μg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

D-019

Dihydrocodeine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

D-021

Dihydrocodeine-D6 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

D-087

Dihydrocodeine-D6 hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Palavra indicadora

Danger

Declarações de precaução

P210 - P260 - P280 - P301 + P310 - P311

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

J O Svensson et al.
Journal of chromatography. B, Biomedical applications, 674(1), 49-55 (1995-12-01)
A reversed-phase ion-pair high-performance liquid chromatographic method for the simultaneous determination of codeine and seven metabolites is described. The samples are purified by reversed-phase solid-phase extraction. Codeine, norcodeine, codeine-6-glucuronide, norcodeine-6-glucuronide and morphine-3-glucuronide are measured with UV detection. Detection limits are
Z R Chen et al.
Journal of chromatography, 491(2), 367-378 (1989-07-21)
A novel high-performance liquid chromatographic method for the determination of codeine, norcodeine and morphine in plasma and urine has been developed. The compounds were separated on a cyano column (15 cm x 4.6 mm, 5 microns particle size) using a
[Morphinan alkaloids present in mammal].
Y M Ning et al.
Sheng li ke xue jin zhan [Progress in physiology], 21(4), 329-332 (1990-10-01)
A Somogyi et al.
European journal of clinical pharmacology, 41(4), 379-382 (1991-01-01)
Plasma and urine concentrations of codeine and its measurable metabolites were determined by HPLC in six healthy subjects after a single 30 mg oral dose of codeine either alone or after 7 doses of 1 g paracetamol 8 hourly. After
C L O'Neal et al.
Forensic science international, 95(1), 1-10 (1998-08-27)
Acetylcodeine (AC), an impurity of illicit heroin synthesis, was investigated as a urinary biomarker for detection of illicit heroin use. One hundred criminal justice urine specimens that had been confirmed positive by GC/MS for morphine at concentrations > 5000 ng/ml
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica