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Documentos Principais

C-106

Supelco

Cortisol solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sinônimo(s):

Hydrocortisone solution, 17-Hydroxycorticosterone, Cortisol

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About This Item

Número CAS:
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.

grau

certified reference material

Formulário

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

1.0 mg/mL in methanol

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing
clinical testing

Formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

chave InChI

JYGXADMDTFJGBT-VWUMJDOOSA-N

Informações sobre genes

human ... NR3C1(2908)

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Descrição geral

Cortisol or hydrocortisone, also known as the stress hormone, is aglucocorticoid steroid. It is released by the adrenal glands and is involved inmaintaining the circadian rhythm. The hormone is measured in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing’s syndrome, Addison’s disease, and Sheehan’s syndrome.

Aplicação

This Certified Reference Material (CRM) in solution can also be used as follows:
  • Development of a disposable immunosensor based on direct competitive-enzyme linked immunoassay (DC-ELISA) to determine cortisol in human saliva samples
  • Quantitative analysis of cortisol in human hair samples by a liquid-chromatography-tandem mass spectrometric (LC-MS/MS) method
  • Selective and sensitive analysis of both cortisol and cortisone in human hair samples by an automated solid phase extraction (SPE) method combined with liquid chromatography (LC) coupled to electrospray ionization-tandem mass spectrometry (ESI-MS3)
  • Multi-residue determination of cortisol, cortisone, and their three tetrahydro metabolites from human urine samples by an LC-MS/MS method
  • Human saliva analysis for the estimation of cortisol and cortisone by ionic liquid dispersive liquid-liquid microextraction (IL-DLLME) and liquid chromatography combined with ultra-violet/visible (UV/Vis) detection

Características e benefícios

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

produto relacionado

Nº do produto
Descrição
Preços

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes,Central nervous system

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup


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Certificados de análise (COA)

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Miriam Diane Lense et al.
American journal on intellectual and developmental disabilities, 118(3), 201-210 (2013-06-06)
Williams syndrome (WS) is a neurodevelopmental genetic disorder associated with high rates of anxiety and social issues. We examined diurnal cortisol, a biomarker of the stress response, in adults with WS in novel and familiar settings, and compared these profiles
Maternal distress and childhood wheeze: mechanisms and context.
Anita L Kozyrskyj et al.
American journal of respiratory and critical care medicine, 187(11), 1160-1162 (2013-06-04)
Benjamin P Casavant et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(25), 10111-10116 (2013-06-05)
Although the field of microfluidics has made significant progress in bringing new tools to address biological questions, the accessibility and adoption of microfluidics within the life sciences are still limited. Open microfluidic systems have the potential to lower the barriers
Wanpen Turakitwanakan et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96 Suppl 1, S90-S95 (2013-06-04)
Mindfulness meditation is a method to relax the mind that decreases stress, which otherwise would increase serum cortisol. So, mindfulness meditation should decrease serum cortisol. To study the effect of mindfulness meditation on mental health by using Thai GHQ28 questionaire
Reduced cortisol metabolism during critical illness.
Greet Van den Berghe et al.
The New England journal of medicine, 369(5), 481-481 (2013-08-02)

Artigos

Accurate steroid analysis in blood serum using Supel™ Swift HLB DPX Tips; UTAK and NIST standards.

Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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