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860542P

Avanti

Lactosyl(β) Sphingosine (d18:1)

Avanti Research™ - A Croda Brand 860542P, powder

Sinônimo(s):

D-lactosyl-β1-1′-D-erythro-sphingosine

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5 MG
R$ 1.371,00

R$ 1.371,00

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R$ 1.371,00

About This Item

Fórmula empírica (Notação de Hill):
C30H57NO12
Número CAS:
109785-20-8
Peso molecular:
623.77
Número MDL:
MFCD07374300
Código UNSPSC:
12352211
NACRES:
NA.25

R$ 1.371,00

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Formulário

powder

embalagem

pkg of 1 × 5 mg (860542P-5mg)
pkg of 1 × 50 mg (860542P-50mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 860542P

tipo de lipídio

sphingolipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O

InChI

1S/C30H57NO12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(34)19(31)18-40-29-27(39)25(37)28(22(17-33)42-29)43-30-26(38)24(36)23(35)21(16-32)41-30/h14-15,19-30,32-39H,2-13,16-18,31H2,1H3/b15-14+/t19-,20+,21+,22+,23-,24-,25+,26+,27+,28+,29+,30-/m0/s1

chave InChI

MQKSCOKUMZMISB-GPWKTZPCSA-N

Descrição geral

Lactosyl sphingosine is a glycosylsphingosine (Lyso-GSL), which is found in bovine brain white matter extract.[1]

Aplicação

Lactosyl(β) Sphingosine (d18:1) or D-lactosyl-β1-1′-D-erythro-sphingosine has been used as an internal standard for the quantification of psychosine using tandem mass spectrometry.[2][3] It may be used to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue.[4] It may also be used as a standard to determine the extent of recovery of lyso-neutral glycosphingolipids (lyso-n-GSLs) from the Sephadex column.[5]

Ações bioquímicas/fisiológicas

Lactosyl sphingosine exhibits better hemolytic activity than lysolecithin.[6]

Embalagem

5 mL Amber Glass Screw Cap Vial (860542P-50mg)
5 mL Amber Glass Screw Cap Vial (860542P-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Michael S Marshall et al.
PloS one, 13(2), e0193438-e0193438 (2018-02-27)
α-Synuclein aggregation has been linked to Gaucher's disease (GD) and Krabbe's disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly attributed to the dysregulation of glycosphingolipids in both conditions, specifically to increased galactosylsphingosine (psychosine) content in the
Jacques Bodennec et al.
Journal of lipid research, 44(7), 1413-1419 (2003-05-06)
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral glycosphingolipids (n-GSLs). Lyso-n-GSLs and n-GSLs are initially obtained from
Richard Mair et al.
Cancer research, 78(18), 5408-5418 (2018-07-29)
13C MRI of hyperpolarized [1-13C]pyruvate metabolism has been used in oncology to detect disease, investigate disease progression, and monitor response to treatment with a view to guiding treatment in individual patients. This technique has translated to the clinic with initial
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