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857370P

Avanti

VU0155056

Avanti Research™ - A Croda Brand 857370P, powder

Sinônimo(s):

N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}ethyl)-2-naphthamide

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1 MG
R$ 816,00

R$ 816,00

Previsão de entrega em26 de abril de 2025

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1 MG
R$ 816,00

About This Item

Fórmula empírica (Notação de Hill):
C25H26N4O2
Número CAS:
1130067-18-3
Peso molecular:
414.50
Número MDL:
MFCD00037705
Código UNSPSC:
12352211
NACRES:
NA.25

R$ 816,00

Previsão de entrega em26 de abril de 2025

Solicite uma grande encomenda

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 1 × 1 mg (857370P-1mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 857370P

tipo de lipídio

bioactive lipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Aplicação

VU0155056 has been used as a phospholipase D-1 (PLD1) inhibitor:
  • to study its role in regulated exocytosis[1]
  • to test bacterial and human PLD enzymes for specificity of inhibition[2]
  • in neuro-2a (N2a) cell culture and survival assay[3]

Ações bioquímicas/fisiológicas

VU0155056 or N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl ethyl)-2-naphthamide is a cell permeable phospholipase D (PLD) inhibitor. It inhibits both PLD1 and PLD2.[4]

Embalagem

5 mL Amber Glass Screw Cap Vial (857370P-1mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

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Certificados de análise (COA)

Lot/Batch Number

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Aditya Kulkarni et al.
Chemical biology & drug design, 84(3), 270-281 (2014-03-20)
Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based
Michael A Kennedy et al.
PLoS genetics, 7(2), e1001299-e1001299 (2011-02-25)
During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not its immediate precursor 1-O-hexadecyl-sn-glycerophosphocholine (C16:0 lyso-PAF), participates
Sarah McDavid et al.
PloS one, 9(10), e109203-e109203 (2014-10-03)
Butanol (C4H10OH) has been used both to dissect the molecular targets of alcohols/general anesthetics and to implicate phospholipase D (PLD) signaling in a variety of cellular functions including neurotransmitter and hormone exocytosis. Like other primary alcohols, 1-butanol is a substrate
Sarah A Scott et al.
Nature chemical biology, 5(2), 108-117 (2009-01-13)
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic acid participates in both G protein-coupled receptor and receptor tyrosine kinase signal transduction networks. The lack of potent and isoform-selective inhibitors
Tatiana P Rogasevskaia et al.
The Journal of biological chemistry, 290(48), 28683-28696 (2015-10-04)
There are a diversity of interpretations concerning the possible roles of phospholipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of regulated exocytosis. To quantitatively address functional and molecular aspects of the involvement of phospholipase

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