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857135P

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18:1 BMP (S,S)

sn-(3-oleoyl-2-hydroxy)-glycerol-1-phospho-sn-1′-(3′-oleoyl-2′-hydroxy)-glycerol (ammonium salt), powder

Sinônimo(s):

lysobisphosphatidic acid; LBPA

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About This Item

Fórmula empírica (Notação de Hill):
C42H82NO10P
Número CAS:
1246303-12-7
Peso molecular:
792.07
Código UNSPSC:
51191904
NACRES:
NA.25

Ensaio

>99% (BMP (contains 30% positional isomers), TLC)

forma

powder

embalagem

pkg of 1 × 10 mg (857135P-10mg)
pkg of 1 × 5 mg (857135P-5mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 857135P

tipo de lipídio

cardiolipins
phospholipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@](COP(OC[C@@]([H])(O)COC(CCCCCCC/C=C\CCCCCCCC)=O)([O-])=O)(O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

Descrição geral

Bis(monoacylglycerol) phosphate (BMP) is a phospholipid containing two-phosphate linked fatty acid esterified glycerol molecule. It is present in late endosome, majorly in intraluminal vesicles (ILVs) and is hydrolyzed by BMP hydrolase. BMP accounts to 15% of total organelle lipids.

Aplicação

18:1 BMP (S,S) may be used as an external standard for calibration in ultra performance liquid chromatography-mass spectrometry (UPLC-MS) and as an internal standard in liquid chromatography - tandem mass spectrometer (LC-MS) for quantification of lipids from tissues.It may also be used in liposome preparation for dengue virus fusion studies.

Ações bioquímicas/fisiológicas

Bis(monoacylglycerol)phosphate (BMP) plays a key role in cargo sorting and protein and lipid trafficking. The levels of BMP is elevated in lysosomal storage disorders (LSD) including Wolman disease, Niemann Pick disease and neuronal ceroid lipofuscinoses. It is resistant to degradation by the enzyme, acid phospholipase.

Embalagem

5 mL Clear Glass Sealed Ampule (857135P-10mg)
5 mL Clear Glass Sealed Ampule (857135P-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Dengue virus ensures its fusion in late endosomes using compartment-specific lipids
Zaitseva E, et al.
PLoS Pathogens, 6(10), e1001131-e1001131 (2010)
Metabolic disease and ABHD6 alter the circulating bis (monoacylglycerol) phosphate profile in mice and humans
Grabner GF, et al.
Journal of Lipid Research, jlr-M093351 (2019)
Group XV phospholipase A2, a lysosomal phospholipase A2.
Shayman J A, et al.
Progress in Lipid Research, 50(1), 1-13 (2011)
Elena Zaitseva et al.
PLoS pathogens, 6(10), e1001131-e1001131 (2010-10-16)
Many enveloped viruses invade cells via endocytosis and use different environmental factors as triggers for virus-endosome fusion that delivers viral genome into cytosol. Intriguingly, dengue virus (DEN), the most prevalent mosquito-borne virus that infects up to 100 million people each
Hirotami Matsuo et al.
Science (New York, N.Y.), 303(5657), 531-534 (2004-01-24)
What are the components that control the assembly of subcellular organelles in eukaryotic cells? Although membranes can clearly be distorted by cytosolic factors, very little is known about the intrinsic mechanisms that control the biogenesis, shape, and organization of organellar

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