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Documentos Principais

850371C

Avanti

22:0 PC

1,2-dibehenoyl-sn-glycero-3-phosphocholine, chloroform

Sinônimo(s):

1,2-didocosanoyl-sn-glycero-3-phosphocholine; PC(22:0/22:0)

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About This Item

Fórmula empírica (Notação de Hill):
C52H104NO8P
Número CAS:
Peso molecular:
902.36
Número MDL:
Código UNSPSC:
51191904
NACRES:
NA.25

Ensaio

>99% (TLC)

Formulário

liquid

embalagem

pkg of 1 × 2.5 mL (850371C-25mg)
pkg of 1 × 20 mL (850371C-500mg)

fabricante/nome comercial

Avanti Research - A Croda Brand 850371C

concentração

10 mg/mL (850371C-25mg)
25 mg/mL (850371C-500mg)

tipo de lipídio

cardiolipins
phospholipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[P](=O)([O-])(OCC[N+](C)(C)C)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC

InChI

1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3

chave InChI

HRTBOPUWPUXROO-UHFFFAOYSA-N

Descrição geral

Phosphatidylcholines are phospholipids, that are abundantly present in the membrane. They have fatty acids in the sn-1 and sn-2 positions, that are covalently attached to a glycerol with the help of ester bonds.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Aplicação

22:0 PC may be used:
  • to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity
  • to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)
  • as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC)

Ações bioquímicas/fisiológicas

The physical properties of membranes can be modulated with the help of fatty acyl configuration of phosphatidylcholines. They act as a vital source for eicosanoids.

Embalagem

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850371C-500mg)
5 mL Clear Glass Sealed Ampule (850371C-25mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Órgãos-alvo

Liver,Kidney, Respiratory system

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash


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Certificados de análise (COA)

Lot/Batch Number

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Elinor Thompson et al.
Healthcare technology letters, 6(5), 138-142 (2019-12-14)
Oxygen loaded microbubbles are being investigated as a means of reducing tumour hypoxia in order to improve response to cancer therapy. To optimise this approach, it is desirable to be able to measure changes in tissue oxygenation in real-time during
K Maloney et al.
Chemistry & biology, 3(3), 185-192 (1996-03-01)
Chemical information is sometimes transmitted across cell membranes by ligand-induced assembly of receptors. We have previously designed a series of lipids with metal-chelating headgroups that can serve as general receptors for proteins containing accessible histidines. Such lipids can also be
Estelle Beguin et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 23-33 (2019-11-17)
Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study
Pinunta Nittayacharn et al.
Frontiers in pharmacology, 11, 644-644 (2020-06-02)
Drug delivery to solid tumors using echogenic nanobubbles (NBs) and ultrasound (US) has recently gained significant interest. The approach combines attributes of nanomedicine and the enhanced permeation and retention (EPR) effect with the documented benefits of ultrasound to improve tumor
Bingbing Cheng et al.
Scientific reports, 9(1), 20020-20020 (2019-12-29)
Real-time acoustic feedback control based on harmonic emissions of stimulated microbubbles may be important for facilitating the clinical adoption of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening, both to ensure safe acoustic exposures, and to achieve repeatable and consistent opening.

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