Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

700116P

Avanti

7-dehydrocholesterol-d7

7-dehydrocholesterol-d7, powder

Sinônimo(s):

111110

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

1 MG
R$ 1.841,00

R$ 1.841,00

Check Cart for Availability
Solicite uma grande encomenda
Todas as fotos(1)

Selecione um tamanho

Alterar visualização
1 MG
R$ 1.841,00

About This Item

Fórmula empírica (Notação de Hill):
C27H37D7O
Número CAS:
388622-58-0
Peso molecular:
391.68
Número MDL:
MFCD22570234
Código UNSPSC:
41141804
NACRES:
NA.25

R$ 1.841,00

Check Cart for Availability
Solicite uma grande encomenda

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 1 × 1 mg (700116P-1mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 700116P

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

cadeia de caracteres SMILES

O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@@H](CC[C@@H]4[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)C3=CC=C2C1)C)C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D

chave InChI

UCTLRSWJYQTBFZ-UDEPUTHCSA-N

Descrição geral

7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes.[1] 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3.[1] The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol.[2] 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.

Aplicação

7-dehydrocholesterol-d7 has been used:
  • as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis[3]
  • in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis[4]
  • to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis[2]

Ações bioquímicas/fisiológicas

7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. [5] Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).[2]

Embalagem

5 mL Amber Glass Screw Cap Vial (700116P-1mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.

Se precisar de ajuda, entre em contato Atendimento ao cliente

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 5

1 of 5

Acetoacetyl-13C4 coenzyme A lithium salt hydrate 99 atom % 13C, 95% (CP)

Sigma-Aldrich

736570

Acetoacetyl-13C4 coenzyme A lithium salt hydrate

18:2 Cardiolipin-d5 Avanti Research™ - A Croda Brand

Avanti

791108C

18:2 Cardiolipin-d5

Cardiolipin Mix I Avanti Research™ - A Croda Brand

Avanti

LM6003

Cardiolipin Mix I

Cholesterol-2,3,4-13C3 99 atom % 13C, 98% (CP)

Sigma-Aldrich

749478

Cholesterol-2,3,4-13C3

cholesterol-d7 Avanti Research™ - A Croda Brand

Avanti

700041P

cholesterol-d7

Andrzej T Slominski et al.
PloS one, 4(2), e4309-e4309 (2009-02-05)
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production
Hanul Kim et al.
Frontiers in microbiology, 6, 54-54 (2015-03-12)
Concern about global warming has prompted an intense interest in developing economical methods of producing biofuels. Microalgae provide a promising platform for biofuel production, because they accumulate high levels of lipids, and do not compete with food or feed sources.
Xiao-Jing Guo et al.
Biotechnology for biofuels, 11, 192-192 (2018-07-22)
7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3. Microbial production of 7-DHC from simple carbon has been recognized as an attractive complement to the traditional
Anika V Prabhu et al.
The Journal of biological chemistry, 291(16), 8363-8373 (2016-02-19)
Cholesterol is detrimental to human health in excess but is also essential for normal embryogenesis. Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. 7-Dehydrocholesterol reductase (DHCR7) is the terminal enzyme of cholesterol
Galya Staneva et al.
Langmuir : the ACS journal of surfaces and colloids, 32(6), 1591-1600 (2016-01-20)
7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some metabolic abnormalities, causing an array of symptoms known as Smith-Lemli-Opitz syndrome. Enrichment of cellular membranes with 7-dehydrocholesterol interferes with normal cell-signaling processes, which involve interaction between
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica