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CDS022536

Sigma-Aldrich

Lenalidomide

Sinônimo(s):

3-(7-Amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

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About This Item

Fórmula empírica (Notação de Hill):
C13H13N3O3
Peso molecular:
259.26
Número MDL:
MFCD07772307
Código UNSPSC:
12352200
ID de substância PubChem:
329795811
Preço e disponibilidade não estão disponíveis no momento.

descrição

AldrichCPR

Formulário

powder

cadeia de caracteres SMILES

O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N

InChI

1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

chave InChI

GOTYRUGSSMKFNF-UHFFFAOYSA-N

Informações sobre genes

human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , RBX1(9978)

Aplicação

Lenalidomide is a structural analog of thalidomide, which exhibits excellent anticancer activity against multiple myeloma.[1][2] It can be used in synthesizing multiple derivatives of lenalidomide to study their biological activity.[3] Synthesis of gelator containing lenalidomide, which forms stable gels in 1,4-dioxane has been reported.[4]

Outras notas

Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.

NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH′S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY, (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE, OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY, WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Warning

Frases de perigo

H361d,H373

Classificações de perigo

Repr. 2 - STOT RE 2

Órgãos-alvo

Blood

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma.
Dimopoulos M, et al.
The New England Journal of Medicine, 357(21), 2123-2132 (2007)
Melamine tunable effect in a lenalidomide-based supramolecular self-assembly system via hydrogen bonding.
Gao A, et al.
New. J. Chem., 41(16), 7924-7931 (2017)
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Lopez-Girona A E A, et al.
Leukemia, 26(11), 2326-2326 (2012)
Design, synthesis and biological evaluation of Lenalidomide derivatives as tumor angiogenesis inhibitor.
Hu S, et al.
Bioorganic & Medicinal Chemistry Letters, 27(17), 4075-4081 (2017)
Xiaofei He et al.
Experimental hematology, 86, 21-27 (2020-05-22)
Our previous study revealed that expression of G protein-coupled receptor 68 (GPR68) was upregulated in MDSL cells, a cell line representing myelodysplastic syndromes (MDS), in response to lenalidomide (LEN), and mediated a calcium/calpain proapoptotic pathway. Isx, a GPR68 agonist, enhanced
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