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901330

Sigma-Aldrich

Bis-MPA-NHBoc dendrimer

trimethylol propane core, generation 2

Sinônimo(s):

Bis-MPA dendrimer, NHBoc functionalized dendrimer, PFD-G2-TMP-NH-BOC

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About This Item

Fórmula empírica (Notação de Hill):
C147H242N12O66
Peso molecular:
3233.54
Código UNSPSC:
12162002
NACRES:
NA.23

forma

solid or viscous liquid

peso molecular

generation 2

Nº de grupos de superfície

12

cor

colorless to pale yellow

temperatura de armazenamento

−20°C

Descrição geral

  • Polymer architecture: Dendrimer
  • Generation: 2
  • End Group Functionality: Boc-protected amine
  • No. Surface Groups: 12
  • Calculated Mol. Wt.: 3233.57 g/mol
  • Boc : tert-Butyloxycarbonyl
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

Aplicação

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrimers synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrimers can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Artigos

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

New Multi-Dendrimer Platforms for Supramolecular Assembly

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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