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Sigma-Aldrich

Poly(ethylene glycol) dithiol

average Mn 1,000, thiol

Sinônimo(s):

Polyethylene glycol, PEG dithiol

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About This Item

Fórmula linear:
HSCH2CH2(OCH2CH2)nSH
Código UNSPSC:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) dithiol, average Mn 1,000

forma

solid

peso molecular

average Mn 1,000

adequação da reação

reagent type: cross-linking reagent
reactivity: thiol reactive

pf

29-33 °C

Ω-final

thiol

α-final

thiol

arquitetura do polímero

shape: linear
functionality: homobifunctional

temperatura de armazenamento

2-8°C

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Aplicação

Thiol functionalized nanoparticles may be used in mucoadhesive drug delivery, synthesis of dithiol terminated amphiphilic diblock copolymer, Bidentate dithiol-poly(ethylene glycol)-poly(d,l-lactide) (SH2-PEG-PDLLA). Gold nanoparticles may be easily functionalized with PEG dithiols by simple ligand exchange.

Outras notas

Molecular weight: Mn 900-1,100

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Jian Yang et al.
Biomacromolecules, 15(4), 1346-1354 (2014-03-13)
Thiol-modified nanoparticles have potential applications in mucoadhesive drug delivery and have been examined in this regard for topical ocular delivery. In this paper we provide a simple method for the synthesis of a dithiol terminated amphiphilic diblock copolymer. Bidentate dithiol-poly(ethylene
Nadeau J
Introduction to Experimental Biophysics: Biological Methods for Physical Scientists null
Qiang Wei et al.
ACS biomaterials science & engineering, 6(8), 4687-4701 (2021-01-19)
Hydrogels have been widely explored for the delivery of cells in a variety of regenerative medicine applications due to their ability to mimic both the biochemical and physical cues of cell microniches. For bone regeneration, in particular, stiff hydrogels mimicking

Artigos

Injectable Hydrogels for Tissue Regeneration

Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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