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524980

Sigma-Aldrich

Dibutyl phthalate

Dibutyl phthalate

99%

Sinônimo(s):

n-Butyl phthalate, DBP, Phthalic acid dibutyl ester

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About This Item

Fórmula linear:
C6H4-1,2-[CO2(CH2)3CH3]2
Número CAS:
Peso molecular:
278.34
Beilstein:
1914064
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
Ensaio:
99%
p.e.:
340 °C (lit.)
pressão de vapor:
1 mmHg ( 147 °C)
Preço e disponibilidade não estão disponíveis no momento.

densidade de vapor

9.6 (vs air)

Nível de qualidade

pressão de vapor

1 mmHg ( 147 °C)

Ensaio

99%

Formulário

liquid

temperatura de autoignição

756 °F

Lim. expl.

0.47 %, 236 °F

Impurezas

≤0.005% Acidity (as Phthalic acid)
≤0.15% water

cor

APHA: ≤20

índice de refração

n20/D 1.492 (lit.)

pH

7 (20 °C, 10 mg/L)

p.e.

340 °C (lit.)

pf

−35 °C (lit.)

densidade

1.043 g/mL at 25 °C (lit.)

grupo funcional

ester

cadeia de caracteres SMILES

CCCCOC(=O)c1ccccc1C(=O)OCCCC

InChI

1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3

chave InChI

DOIRQSBPFJWKBE-UHFFFAOYSA-N

Informações sobre genes

mouse ... Esr1(13982)

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Descrição geral

Dibutyl phthalate (DBP) is most commonly used as a plasticizer in a variety of household products. It has the ability to leach and evaporate into the environment while using or disposing of these products.[1][2] Therefore, studies are being conducted to assess its toxic and apoptotic effects.[1] Studies have also indicated that exposure to high doses of DBP may interfere with progesterone and estradiol production.[2]

Aplicação

Plasticizer

Pictogramas

Health hazardEnvironment

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 2 - Repr. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

367.7 °F - open cup

Ponto de fulgor (°C)

186.5 °C - open cup

Equipamento de proteção individual

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Slide 1 of 2

1 of 2

Dibutyl phthalate (DBP)-induced apoptosis and neurotoxicity are mediated via the aryl hydrocarbon receptor (AhR) but not by estrogen receptor alpha (ER?), estrogen receptor beta (ER?), or peroxisome proliferator-activated receptor gamma (PPAR?) in mouse cortical neurons.
Wojtowicz A
Neurotoxicity Research, 31(1), 77-89 (2017)
Dibutyl phthalate impairs steroidogenesis and a subset of LH-dependent genes in cultured human mural granulosa cell in vitro.
Adir M
Reproductive Toxicology, 69, 13-18 (2017)
Damien Hunter et al.
International journal of molecular sciences, 22(8) (2021-05-01)
Xenobiotic exposure during pregnancy and lactation has been linked to perinatal changes in male reproductive outcomes and other endocrine parameters. This pilot study wished to assess whether brief maternal exposure of rats to xenobiotics dibutyl phthalate (DBP) or diethylstilbestrol (DES)
Linda V Sinclair et al.
Immunometabolism, 2(4), e200029-e200029 (2020-09-04)
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose (2-NBDG), a fluorescent analogue of 2-deoxyglucose (2DG), as a substrate
Harpreet Bhatia et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 103-115 (2014-03-01)
Phthalic acid esters (PAEs) are a class of synthetic industrial chemicals commonly found in the aquatic environment worldwide. PAEs have been recognised as anti-androgens in male mammals but little is known about their endocrine disrupting effects in fish. This study

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. En que esta disuelto? a que concentración?

    1 answer
    1. This item is in liquid form with a purity of greater than or equal to 99.0%; it is not mixed with anything. Please see the sample Certificate of Anaylsis here: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/524980-BULKMKCV6253.pdf

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  4. Buenos días, Me gustaría confirmar si el formato "poly bottle" se trata de una botella de plástico y en su caso, si existe algún tipo de diferencia entre los formatos de 25 y 100 mL, puesto que la diferencia de precio es mínima.

    1 answer
    1. Item 524980-25ML is packaged in a HDPE plastic bottle and 524980-100ML is packaged in an amber glass bottle.

      Helpful?

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