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424048

Sigma-Aldrich

2,6-Quinolinediol

Sinônimo(s):

2,6-Dihydroxyquinoline, 6-Hydroxycarbostyril

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About This Item

Fórmula empírica (Notação de Hill):
C9H7NO2
Número CAS:
19315-93-6
Peso molecular:
161.16
Número MDL:
MFCD00239446
Código UNSPSC:
12352100
ID de substância PubChem:
24866548
NACRES:
NA.22

pf

>300 °C (lit.)

cadeia de caracteres SMILES

Oc1ccc2nc(O)ccc2c1

InChI

1S/C9H7NO2/c11-7-2-3-8-6(5-7)1-4-9(12)10-8/h1-5,11H,(H,10,12)

chave InChI

AQLYZDRHNHZHIS-UHFFFAOYSA-N

Descrição geral

2,6-Quinolinediol is a substituted quinoline compound. It has been prepared starting from 6-methoxyquinoline. It has been reported to be one of the UV-absorbing compounds (UAC) found in cow milk.

Aplicação

2,6-Quinolinediol may be used as a test compound to investigate the carcinogenicity of the naturally occurring quinoline metabolite of tryptophan. The study was conducted by suspending tryptophan metabolites in cholesterol pellets, followed by the surgical implantation of the pellets into the mice bladder. It may be used as a reactant in the synthesis of 2-chloro-6-quinolinol by reacting with POCl3 (phosphorus oxychloride).
Reactant involved in synthesis of:
  • (Benzyloxy)methylquinolinone derivatives for use as PDE3 inhibitors
  • Substances related to cilostazol
  • 2,6-Quinolinyl derivatives for use as VLA-4 / VCAM-1 antagonists

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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In vivo elution of tryptophan metabolites and other aromatic nitrogen compounds from cholesterol pellets implanted into mouse bladders.
Bryan GT, et al.
Cancer Research, 24(4), 586-595 (1964)
2, 6-Quinolinyl derivatives as potent VLA-4 antagonists.
Lassoie MA, et al.
Bioorganic & Medicinal Chemistry Letters, 17(1), 142-146 (2007)
Mouse bladder carcinogenicity of certain tryptophan metabolites and other aromatic nitrogen compounds suspended in cholesterol.
Bryan GT, et al.
Cancer Research, 24(4), 596-602 (1964)
Pascal Rouge et al.
Food chemistry, 141(3), 1888-1894 (2013-07-23)
The aim of this work was to characterise new UV-absorbing compounds (UAC) in cow milk in order to gain an overview of the molecular diversity of the minor bioactive constituents, that could be used to trace animal feed or that

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