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363057

Sigma-Aldrich

6-O-Methylguanine

97%

Sinônimo(s):

2-Amino-6-methoxypurine, 6-Methoxyguanine

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About This Item

Fórmula empírica (Notação de Hill):
C6H7N5O
Número CAS:
20535-83-5
Peso molecular:
165.15
Beilstein:
645384
Número MDL:
MFCD00133009
Código UNSPSC:
12352100
ID de substância PubChem:
24862349
NACRES:
NA.22

Ensaio

97%

pf

>300 °C (lit.)

cadeia de caracteres SMILES

COc1nc(N)nc2[nH]cnc12

InChI

1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)

chave InChI

BXJHWYVXLGLDMZ-UHFFFAOYSA-N

Informações sobre genes

human ... CDK2(1017) , MGMT(4255)

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Descrição geral

6-O-Methylguanine is a purine derivative and its binding affinity has been examined by B. subtilis xpt-pbuX guanine riboswitch (GR) using isothermal titration calorimetry (ITC). 6-O-Methylguanine is formed during the alkylation of a number of purified tRNA preparations, via reaction with the carcinogens, N-methyl-N-nitrosourea .

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Biuret 98% (Contains ≤10%(w/w) Triuret)

Sigma-Aldrich

15270

Biuret

Wynand P Roos et al.
Cancer letters, 332(2), 237-248 (2012-01-21)
DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the apoptotic executing pathways
Sunny D Gilbert et al.
Structure (London, England : 1993), 17(6), 857-868 (2009-06-16)
Purine riboswitches discriminate between guanine and adenine by at least 10,000-fold based on the identity of a single pyrimidine (Y74) that forms a Watson-Crick base pair with the ligand. To understand how this high degree of specificity for closely related
N R Jena et al.
Physical biology, 8(4), 046007-046007 (2011-06-15)
Methylated guanine damage at O6 position (i.e. O6MG) is dangerous due to its mutagenic and carcinogenic character that often gives rise to G:C-A:T mutation. However, the reason for this mutagenicity is not known precisely and has been a matter of
Anna V Knizhnik et al.
PloS one, 8(1), e55665-e55665 (2013-02-06)
Apoptosis, autophagy, necrosis and cellular senescence are key responses of cells that were exposed to genotoxicants. The types of DNA damage triggering these responses and their interrelationship are largely unknown. Here we studied these responses in glioma cells treated with
Mindy Reynolds et al.
Mutagenesis, 27(4), 437-443 (2012-01-14)
Cultured human cells are invaluable biological models for mechanistic studies of genotoxic chemicals and drugs. Continuing replacement of animals in toxicity testing will further increase the importance of in vitro cell systems, which should accurately reproduce key in vivo characteristics
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