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Sigma-Aldrich

Phosphonoacetic acid

98%

Sinônimo(s):

(Carboxymethyl)phosphonic acid, 2-Phosphonoacetic acid, Fosfonoacetic acid, Phosphonacetic acid

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R$ 902,00
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About This Item

Fórmula linear:
(HO)2P(O)CH2CO2H
Número CAS:
4408-78-0
Peso molecular:
140.03
Número CE:
224-558-1
Número MDL:
MFCD00004311
Código UNSPSC:
12352100
ID de substância PubChem:
24857145
NACRES:
NA.22

R$ 902,00

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Nível de qualidade

100

Ensaio

98%

Formulário

powder or crystals

pf

143-146 °C (lit.)

solubilidade

water: soluble 100 mg/mL, clear to very slightly hazy, colorless

grupo funcional

carboxylic acid

cadeia de caracteres SMILES

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

chave InChI

XUYJLQHKOGNDPB-UHFFFAOYSA-N

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Descrição geral

Phosphonoacetic acid inhibits specifically human cytomegalovirus DNA synthesis in virus-infected human fibroblasts[1]. It also inhibits the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro[2].

Aplicação

Phosphonoacetic acid was used as an inhibitor of viral DNA replication, to investigate the infected cell protein 0 (bICP0) localization in infected low passage bovine cells[3]. It was also used as a phosphorus source for microbial growth in phosphate-independent manner[4].

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
MKCW3645
MKCT6904
MKCT0828
MKBC4049
03598PJ

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Phosphonoacetic acid solution TraceCERT®, 31P-qNMR Standard, 5 mg/g in D2O, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

79251

Phosphonoacetic acid solution

Phosphonoacetic acid TraceCERT®, 31P-qNMR Standard, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

96708

Phosphonoacetic acid

Foscarnet sodium British Pharmacopoeia (BP) Reference Standard

BP623

Foscarnet sodium

DL-2-Amino-3-phosphonopropionic acid

Sigma-Aldrich

A4910

DL-2-Amino-3-phosphonopropionic acid

R W Honess et al.
Journal of virology, 21(2), 584-600 (1977-02-01)
Phosphonoacetic acid (PAA) inhibited the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro. In the presence of concentrations of PAA sufficient to prevent virus growth and virus DNA synthesis
Magdalena Klimek-Ochab
Folia microbiologica, 59(5), 375-380 (2014-02-27)
A psychrophilic fungal strain of Geomyces pannorum P15 was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen, or carbon. Only phosphonoacetic acid served as a phosphorus source
Adam D Lietzan et al.
Biochemistry, 50(45), 9708-9723 (2011-10-01)
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the
Vincent Li et al.
Journal of molecular biology, 400(3), 295-308 (2010-05-25)
Structure-based protein sequence alignments of family B DNA polymerases revealed a conserved motif that is formed from interacting residues between loops from the N-terminal and palm domains and between the N-terminal loop and a conserved proline residue. The importance of
Lauren M Oko et al.
PLoS pathogens, 15(6), e1007849-e1007849 (2019-06-06)
Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybridization platform with multiparameter flow cytometry, to study the
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