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222569

Sigma-Aldrich

Fomepizole

99%

Sinônimo(s):

4-Methylpyrazole

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About This Item

Fórmula empírica (Notação de Hill):
C4H6N2
Número CAS:
7554-65-6
Peso molecular:
82.10
Beilstein:
105204
Número CE:
231-445-0
Número MDL:
MFCD00005245
Código UNSPSC:
12352100
ID de substância PubChem:
24853343
NACRES:
NA.22

Ensaio

99%

índice de refração

n20/D 1.495 (lit.)

p.e.

99-100 °C/6 mmHg (lit.)

solubilidade

alcohol: soluble(lit.)
water: soluble(lit.)

densidade

0.993 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

Cc1cn[nH]c1

InChI

1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)

chave InChI

RIKMMFOAQPJVMX-UHFFFAOYSA-N

Informações sobre genes

human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

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Descrição geral

4-Methylpyrazole inhibits CYP2E1 activity[1]. It also acts as alcohol dehydrogenase inhibitor[2].

Aplicação

Fomepizole (4-Methylpyrazole) can be used as:
  • A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.[3]
  • A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.[4]
  • A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.[5]

Useful as an antidote in methanol and ethylene glycol poisoning.

Ações bioquímicas/fisiológicas

Alcohol dehydrogenase inhibitor
Alcohol dehydrogenase inhibitor.[6]

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319,H335

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

204.8 °F - closed cup

Ponto de fulgor (°C)

96 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análise (COA)

Lot/Batch Number
0000144428
0000136354
0000136355
0000117046
0000124987

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Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
Marisa Battistella
The Annals of pharmacotherapy, 36(6), 1085-1089 (2002-05-23)
To assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis. A MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search
Jafar Shahraki et al.
Iranian journal of pharmaceutical research : IJPR, 12(4), 829-844 (2014-02-14)
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes
Raido Paasma et al.
Clinical toxicology (Philadelphia, Pa.), 50(9), 823-831 (2012-09-21)
INTRODUCTION. Thorough prognostic and metabolic studies of methanol poisonings are scarce. Our aims were to evaluate the factors associated with sequelae and death from methanol poisoning, to develop a simple risk-assessment chart to evaluate factors associated with sequelae and death
Katariina Nurmi et al.
PloS one, 8(11), e78537-e78537 (2013-11-19)
In the pathogenesis of coronary atherosclerosis, local macrophage-driven inflammation and secretion of proinflammatory cytokines, interleukin-1β (IL-1β) in particular, are recognized as key factors. Moderate alcohol consumption is associated with a reduced risk of coronary artery disease mortality. Here we examined
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