176141

4-Hydroxy-TEMPO

95%

• Sinônimo(s): 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl, TEMPOL
• Fórmula empírica (Notação de Hill): C₉H₁₈NO₂
• Número CAS: 2226-96-2
• Peso molecular: 172.24
• Beilstein: 1422990
• Número CE: 218-760-9
• Número MDL: MFCD00006478
• Código UNSPSC: 12352119
• ID de substância PubChem: 24850555
• NACRES: NA.22

Propriedades

• Ensaio: 95%
• forma: solid
• composição: Carbon content, 60.6-65.0% ; Nitrogen content, 7.8-8.4%
• pf: 69-71 °C (lit.)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC1(C)CC(O)CC(C)(C)N1[O]
• InChI: 1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
• chave InChI: UZFMOKQJFYMBGY-UHFFFAOYSA-N

Descrição

Descrição geral

4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic.

Aplicação

4-Hydroxy-TEMPO (HO-TEMPO) may be employed as catalyst for the oxidation of alcohols to the corresponding aldehydes. It may be employed for the preparation of TEMPO based polymer catalyst systems, which are useful for the Anelli oxidation of various primary alcohols. It may be used as starting reagent in the synthesis of 4-(2,2,6,6-tetramethyl-1-oxyl-4-piperidoxyl)butyl bromide.

A fluorous-tagged TEMPO derivative was prepared from the derived TEMPO propargylic ether and subsequent "click" reaction with a fluorous azide. This TEMPO derivative proved to be a highly effective catalyst in the oxidation of alcohols with bleach.

Spin label for studying biological compounds and polymers.

Spin label reagent used in the chatacterization of antagonist and agonist binding sites of NK₁ receptor. Also used to measure reactive oxygen generation in heart muscle by electron spin resonance spectroscopy. Cells that overexpress CYP2E1 can be protected from arachidonic acid toxicity damage by TEMPOL.

Informações de segurança

• Pictogramas: GHS08,GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H318,H373
• Declarações de precaução: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Classificações de perigo: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2 Oral
• Órgãos-alvo: Liver,spleen
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 294.8 °F - DIN 51758
• Ponto de fulgor (°C): 146 °C - DIN 51758
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves