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120685

Sigma-Aldrich

N-Cyclohexylformamide

99%

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About This Item

Fórmula linear:
HCONHC6H11
Número CAS:
766-93-8
Peso molecular:
127.18
Número MDL:
MFCD00003828
Código UNSPSC:
12352100
ID de substância PubChem:
24847425
NACRES:
NA.22

Ensaio

99%

forma

solid

pb

113 °C/700 mmHg (lit.)

pf

36-41 °C (lit.)

cadeia de caracteres SMILES

O=CNC1CCCCC1

InChI

1S/C7H13NO/c9-6-8-7-4-2-1-3-5-7/h6-7H,1-5H2,(H,8,9)

chave InChI

SWGXDLRCJNEEGZ-UHFFFAOYSA-N

Informações sobre genes

human ... ADH1A(124) , ADH1B(125) , ADH1C(126) , ADH4(127) , ADH7(131) , EPHX2(2053)
mouse ... Ephx2(13850)

Categorias relacionadas

Descrição geral

N-Cyclohexylformamide binds to the complex of horse liver alcohol dehydrogenase with NADH and is similar to the Michaelis complex for aldehyde reduction catalyzed by the enzyme. It is formed during hydration of cyclohexyl isocyanide catalyzed by a novel enzyme isonitrile hydratase from Pseudomonas putida N19-2 .

Aplicação

N-Cyclohexylformamide was used in the synthesis of 2-methylidene-1,3-selenazolidine derivatives.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Frases de perigo

H302,H315,H318,H335

Declarações de precaução

P261 - P280 - P305 + P351 + P338

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

>235.4 °F - closed cup

Ponto de fulgor (°C)

> 113 °C - closed cup

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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N,N-Dimetilformamida

H Deng et al.
Biochemistry, 37(40), 14267-14278 (1998-10-07)
The binding of N-cyclohexylformamide (CXF) to the complex of horse liver alcohol dehydrogenase with NADH mimics that of the Michaelis complex for aldehyde reduction catalyzed by the enzyme. The Raman spectra of bound CXF and its 13C- and 15N-substituted derivatives
M Goda et al.
The Journal of biological chemistry, 276(26), 23480-23485 (2001-04-18)
Isonitrile containing an N triple bond C triple bond was degraded by microorganism sp. N19-2, which was isolated from soil through a 2-month acclimatization culture in the presence of this compound. The isonitrile-degrading microorganism was identified as Pseudomonas putida. The
Selenium-containing heterocycles from isoselenocyanates: synthesis of 2-methylidene-1, 3-selenazolidine derivatives.
Sommen GL, et al.
Tetrahedron, 62(14), 3344-3354 (2006)
S Ramaswamy et al.
Biochemistry, 36(12), 3522-3527 (1997-03-25)
Amides are analogs of aldehydes and potent inhibitors of liver alcohol dehydrogenases. They can be used for structural studies and for inhibiting the metabolism of alcohols that form toxic products. We studied N-alkyl amides that bind to the enzyme-NADH complex
S Svensson et al.
Journal of molecular biology, 302(2), 441-453 (2000-09-06)
The structure of mouse class II alcohol dehydrogenase (ADH2) has been determined in a binary complex with the coenzyme NADH and in a ternary complex with both NADH and the inhibitor N-cyclohexylformamide to 2.2 A and 2.1 A resolution, respectively.
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