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Merck

ACHE

acetylcholinesterase

Sinônimos:
ACEE, ARACHE, N-ACHE, YT
Espécies:
ID UniProtKB:
ID do gene:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

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Small Molecule - Activator

Número do produto
Descrição
Espécies
Pyridine-2-aldoxime methochloride, ,
Espécies
human

Small Molecule - Agonist

Número do produto
Descrição
Espécies
Acetylthiocholine chloride, ≥99% (TLC), powder,
Espécies
human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
cat, human, mouse, rabbit, rat
Aplicação
ELISA
flow cytometry

immunofluorescence

western blot
Anti-Acetylcholinesterase (AChE) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
western blot
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
Reatividade de espécies
bovine, canine, chicken, guinea pig, human, monkey
Aplicação
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
Anti-ACHE, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Aplicação
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Scopoletin, ≥99%,
Espécies
human
Pyridostigmine bromide, ,
Espécies
human
Neostigmine bromide, ≥98% (HPLC and titration), powder,
Espécies
human
Neostigmine methyl sulfate, ,
Espécies
human
1,5-Bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide, ,
Espécies
human

Kits

Número do produto
Descrição
Espécies
Acetylcholinesterase Activity Assay Kit, sufficient for 100 colorimetric tests,
Espécies
mouse, human

Proteins

Número do produto
Descrição
Espécies
Acetylcholinesterase human, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry),
Espécies
human
Acetylcholinesterase from human erythrocytes, buffered aqueous solution, ≥500 units/mg protein (BCA),
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human ACHE,
Espécies
human