N2001

Neostigmine bromide

≥98% (HPLC and titration), powder

• Sinônimo(s): 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine
• Fórmula empírica (Notação de Hill): C₁₂H₁₉BrN₂O₂
• Número CAS: 114-80-7
• Peso molecular: 303.20
• Número CE: 204-054-8
• Número MDL: MFCD00011795
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277854
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC and titration)
• Formulário: powder
• cor: white
• pf: 175-177 °C (lit.)
• solubilidade: H₂O: 1 g/mL; ethanol: soluble
• cadeia de caracteres SMILES: [Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
• InChI: 1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
• chave InChI: LULNWZDBKTWDGK-UHFFFAOYSA-M
• Informações sobre genes: human ... ACHE(43)

Descrição

Aplicação

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

• to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.[1]
• to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).[2]
• to study its effects on depolarization of bag cell neurons.[3]

Ações bioquímicas/fisiológicas

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.[4]

Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.

Reversible inhibitor of acetylcholinesterase; does not cross the blood-brain barrier.

Características e benefícios

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300 + H310 + H330,H315,H317,H319,H334,H335
• Declarações de precaução: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges