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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Synonyme(s) :

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Formule empirique (notation de Hill):
C10H6N2O2
Numéro CAS:
118409-57-7
Poids moléculaire :
186.17
Numéro MDL:
MFCD00133899
Code UNSPSC :
12352200
ID de substance PubChem :
24278041
Nomenclature NACRES :
NA.77

Source biologique

synthetic (organic)

Pureté

≥98%

Forme

powder

Puissance

35 μM IC50

Solubilité

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

Température de stockage

2-8°C

Chaîne SMILES 

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

Clé InChI

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Informations sur le gène

human ... CDK2(1017)

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Actions biochimiques/physiologiques

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Janusz Ligęza et al.
Acta biochimica Polonica, 58(3), 391-396 (2011-09-03)
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase
Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
E Heim
Zeitschrift fur Psychosomatische Medizin und Psychoanalyse, 38(3), 207-226 (1992-01-01)
Stressors and health risks in medical professions are still largely ignored. A survey on different studies in nurses, students, doctors and dentists by this author is compared to results of other authors. Special attention is given to role-strain and health
Mikyung Yang et al.
American journal of physiology. Lung cellular and molecular physiology, 294(5), L1007-L1012 (2008-03-18)
We assessed the roles of the protein kinase C (PKC) and the tyrosine kinase (TK) signaling pathways in regulating capacitative calcium entry (CCE) in human pulmonary artery smooth muscle cells (PASMCs) and investigated the effects of intravenous anesthetics (midazolam, propofol
Doan-Trung Luu et al.
The Plant journal : for cell and molecular biology, 69(5), 894-905 (2011-11-05)
The constitutive cycling of plant plasma membrane (PM) proteins is an essential component of their function and regulation under resting or stress conditions. Transgenic Arabidopsis plants that express GFP fusions with AtPIP1;2 and AtPIP2;1, two prototypic PM aquaporins, were used
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