The recommended storage temperature for this product is for –20°C. The stability of this product at –80°C has not been evaluated. This compound is not directly soluble in water. However, product R9532, Pyocyanin, Ready Made Solution, is a 5 mg/mL solution in DMSO. This item has a general shelf live of 2 years at –20°C. The prepared solution is not stable when stored at refrigerated temperatures. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/429/027/p0046dat.pdf
P0046
Pyocyanin
from Pseudomonas aeruginosa, ≥98% (HPLC), solid, redox-active phenazine
Synonyme(s) :
5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin
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5 MG
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25 MG
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About This Item
Formule empirique (notation de Hill):
C13H10N2O
Numéro CAS:
Poids moléculaire :
210.23
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
137,00 €
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Nom du produit
Pyocyanin, from Pseudomonas aeruginosa, ≥98% (HPLC)
Source biologique
Pseudomonas aeruginosa
Niveau de qualité
Essai
≥98% (HPLC)
Forme
solid
Solubilité
DMSO: soluble
acetone: soluble
chloroform: soluble
ethanol: soluble
Conditions d'expédition
wet ice
Température de stockage
−20°C
Chaîne SMILES
CN1c2ccccc2N=C3C(=O)C=CC=C13
InChI
1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3
Clé InChI
YNCMLFHHXWETLD-UHFFFAOYSA-N
Actions biochimiques/physiologiques
Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines.
Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.
Notes préparatoires
For the preparation of an aqueous solution, dissolve pyocyanin in ethanol using 10% of the final required volume and then add distilled water to complete the volume.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Eye Irrit. 2
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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