I8779
Insulin-like Growth Factor-I from mouse
IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonyme(s) :
IGF-I
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About This Item
Produits recommandés
Source biologique
mouse
Niveau de qualité
Produit recombinant
expressed in E. coli
Pureté
≥98% (SDS-PAGE and HPLC)
Forme
lyophilized powder
Qualité
endotoxin tested
Poids mol.
predicted mol wt ~7.6 kDa
Conditionnement
glass bottle of 50 μg (in glass insert)
Technique(s)
cell culture | mammalian: suitable
Impuretés
<0.1 ng/mg (LAL test)
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... IGF1(3479)
mouse ... Igf1(16000)
Catégories apparentées
Description générale
Insulin-like growth factor I (IGF-I) belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules. IGF-I is also known as somatomedin. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells.
Application
Insulin-like Growth Factor-I from mouse has been used:
- for the preparation of growth factor cocktail
- as a media supplement for mouse embryonic fibroblasts culture
- as a media supplement to serve as a positive control to investigate
- the effects of Angelica sinensis on myotubes
Actions biochimiques/physiologiques
Insulin-like growth factor I (IGF-I) plays critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.
IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
Potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Mouse and human IGF-I share 97% sequence identity.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Remarque sur l'analyse
The biological activty is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line, MCF-7.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
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Articles
Insulin-like Growth Factors (IGF)
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