Accéder au contenu
Merck
Toutes les photos(3)

Key Documents

View All Documentation

F6300

Sigma-Aldrich

Flumazenil

>99% (HPLC), solid, benzodiazepine receptor antagonist

Synonyme(s) :

Ro 15-1788, Ro15-1788

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(3)

About This Item

Formule empirique (notation de Hill):
C15H14FN3O3
Numéro CAS:
78755-81-4
Poids moléculaire :
303.29
Numéro MDL:
MFCD00242764
Code UNSPSC :
12352200
ID de substance PubChem :
24278437
Nomenclature NACRES :
NA.77

product name

Flumazenil, >99% (HPLC), solid

Niveau de qualité

100

Pureté

>99% (HPLC)

Forme

solid

Couleur

white

Auteur

Roche

Température de stockage

2-8°C

Chaîne SMILES 

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

Clé InChI

OFBIFZUFASYYRE-UHFFFAOYSA-N

Informations sur le gène

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706) , Gabrg1(140674)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

Actions biochimiques/physiologiques

Highly specific benzodiazepine receptor antagonist.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 8

1 of 8

CITCO ≥98% (HPLC), solid

Sigma-Aldrich

C6240

CITCO

Omeprazole solid

Sigma-Aldrich

O104

Omeprazole

Phaclofen solid

Sigma-Aldrich

P118

Phaclofen

Ramelteon

Sigma-Aldrich

SML2262

Ramelteon

Galantamine Hydrobromide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1623

Galantamine Hydrobromide

(+)-Bicuculline ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicuculline

PK 11195

Sigma-Aldrich

C0424

PK 11195

Luzindole ≥90%

Sigma-Aldrich

L2407

Luzindole

Nahid Amini et al.
Analytical and bioanalytical chemistry, 405(4), 1303-1310 (2012-11-28)
A general method is presented for the identification of radiometabolites in plasma of human and monkey subjects after administration of positron emission tomography (PET) radioligands. The radiometabolites are first produced in vitro, using liver microsomes, subsequently separated using fast radio-liquid
Stina Syvänen et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(12), 1974-1983 (2012-11-13)
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study
David B Rye et al.
Science translational medicine, 4(161), 161ra151-161ra151 (2012-11-24)
The biology underlying excessive daytime sleepiness (hypersomnolence) is incompletely understood. After excluding known causes of sleepiness in 32 hypersomnolent patients, we showed that, in the presence of 10 μM γ-aminobutyric acid (GABA), cerebrospinal fluid (CSF) from these subjects stimulated GABA(A)
Wolf-Dieter Heiss
Annals of the New York Academy of Sciences, 1268, 26-34 (2012-09-22)
An ischemic penumbra has the potential for functional recovery provided that local blood flow can be reestablished, but irreversible damage will develop without sufficient reperfusion, depending on the interaction of severity and duration of ischemia. With acute flows below the
Suengmok Cho et al.
Psychopharmacology, 231(14), 2825-2837 (2014-02-04)
In psychopharmacology, researchers have been interested in the hypnotic effects of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant polyphenol, could have potential as a source of novel hypnotic drugs. The effects of phlorotannins and major phlorotannin
Afficher tous les articles scientifiques apparentés

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique