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902551

Sigma-Aldrich

BocNH-PEG4-acid

Synonyme(s) :

2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH

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About This Item

Formule empirique (notation de Hill):
C15H29NO8
Numéro CAS:
876345-13-0
Poids moléculaire :
351.39
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.22

Forme

liquid

Capacité de réaction

reaction type: Pegylations

Pertinence de la réaction

reagent type: cross-linking reagent

Indice de réfraction

n/D 1.4641

Densité

1.1395 g/mL

Groupe fonctionnel

Boc
amine
carboxylic acid

Température de stockage

−20°C

Chaîne SMILES 

OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Autres remarques

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Jennifer L Brigham et al.
ACS chemical biology, 8(4), 691-699 (2013-01-12)
Bioorthogonal ligation methods that allow the selective conjugation of fluorophores or biotin to proteins and small molecule probes that contain inert chemical handles are an important component of many chemical proteomic strategies. Here, we present a new catch-and-release enrichment strategy
BisPNA targeting to DNA: Effect of neutral loop on DNA duplex strand invasion by aepPNA-N7GlaepPNA-C substituted peptide nucleic acids
Shirude P S, et sl.
European Journal of Organic Chemistry, 2005, 5207-5215 (2005)
Erin A Losey et al.
Bioconjugate chemistry, 20(2), 376-383 (2009-01-16)
Cellular membranes play key roles in the regulation of a range of important biological processes. However, the characterization of membrane involvement in these events is difficult to achieve due to the complexity of the membrane bilayer and the challenges associated
A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.
Hongjun Ren et al.
Angewandte Chemie (International ed. in English), 48(51), 9658-9662 (2009-11-20)
Pratistha Ranjitkar et al.
Chemistry & biology, 17(2), 195-206 (2010-03-02)
A number of small-molecule inhibitors have been developed that target the catalytic domains of protein kinases that are not in an active conformation. An inactive form that has been observed in several kinases is the DFG-out conformation. This conformation is
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