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Merck

UC211

7-Hydroxywarfarin

Synonym(e):

3-(α-Acetonylbenzyl)-4,7-dihydrocoumarin, 4-7-Dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

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Über diesen Artikel

Empirische Formel (Hill-System):
C19H16O5
CAS-Nummer:
17834-03-6
Molekulargewicht:
324.33
NACRES:
NA.77
PubChem Substance ID:
329827660
UNSPSC Code:
12161501
MDL number:
MFCD00272668

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InChI

1S/C19H16O5/c1-11(20)9-15(12-5-3-2-4-6-12)17-18(22)14-8-7-13(21)10-16(14)24-19(17)23/h2-8,10,15,21-22H,9H2,1H3

SMILES string

CC(CC(C1=C(O)C(C=CC(O)=C2)=C2OC1=O)C3=CC=CC=C3)=O

InChI key

SKFYEJMLNMTTJA-UHFFFAOYSA-N

form

solid

color

white

mp

220 °C

solubility

DMSO: soluble

storage temp.

2-8°C

Quality Level

200

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Dieser Artikel
UC283SML1270SML2365
7-Hydroxywarfarin

Sigma-Aldrich

UC211

7-Hydroxywarfarin

7-Hydroxycoumarin sulfate potassium salt ≥95% (HPLC)

Sigma-Aldrich

UC283

7-Hydroxycoumarin sulfate potassium salt

YZ9 ≥98% (HPLC)

Sigma-Aldrich

SML1270

YZ9

Phenprocoumon ≥97% (HPLC)

Sigma-Aldrich

SML2365

Phenprocoumon

form

solid

form

solid

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: soluble

solubility

H2O: soluble, methanol: soluble

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white

color

white to off-white

color

white to beige

color

white to beige

mp

220 °C

mp

204-205 °C

mp

-

mp

-

Biochem/physiol Actions

CYP2C9 metabolite of (S)-warfarin.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

7-Hydroxywarfarin is soluble in DMSO.

Application

7-Hydroxywarfarin can be used for the metabolic assays of (S)-warfarin.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

hcodes

H302,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000141460
0000141460
0000106199
0000039873
0000092238

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Die Dokumentenbibliothek aufrufen

Xiao-Yang Zhou et al.
Frontiers in pharmacology, 12, 619339-619339 (2021-03-02)
Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness. We analyzed the cytochrome P450 2C9 (CYP2C9) and vitamin
Masahiro Utoh et al.
Biochemical pharmacology, 95(2), 110-114 (2015-03-25)
Cynomolgus monkeys are widely used as non-human primate species in preclinical studies, due to their close evolutionary relationship to humans. Monkey cytochrome P450 2C19 (formerly known as P450 2C75), highly homologous to human P450 2C19, has been identified to be
Tae Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2429-2433 (2008-09-12)
Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated whether these mice have a capacity for drug metabolism similar to that of humans by examining hydroxylation of S-warfarin, which is predominantly metabolized
D Lang et al.
Journal of chromatography. B, Biomedical applications, 672(2), 305-309 (1995-10-20)
The formation of 7-hydroxywarfarin in incubations of (S)-warfarin with human liver microsomes reflects their cytochrome P-4502C9 activity. This paper describes a rapid high-performance liquid chromatographic method for the determination of 7-hydroxywarfarin with high sensitivity, selectivity, and a simple sample clean-up
D J Black et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(4), 422-428 (1996-04-01)
Consistent with expectations based on human in vitro microsomal experiments, administration of fluconazole (400 mg/day) for 6 days to six human volunteers significantly reduced the cytochrome P450 (P450)-dependent metabolic clearance of the warfarin enantiomers. In particular, P4502C9 catalyzed 6- and
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